摘要
随着分子克隆技术的诞生和许多致癌基因编码蛋白激酶的发现,目前人类激酶组已鉴定出538种蛋白激酶[1],约占人类所有基因的2%[2]。蛋白激酶及其同源磷酸酶通过催化可逆的蛋白磷酸化在信号转导中起着重要作用。通过改变底物活性,蛋白激酶控制着许多细胞过程,包括代谢、转录、细胞周期/增殖、细胞骨架重排及细胞迁移、凋亡和分化。
Sucrose non-fermentation 1-related kinase(SNRK)is a serine/threonine kinase which has not been widely studied,also a member of AMP-activated protein kinase family.SNRK is an important mediator to maintain the metabolic homeostasis of various cells,especially in the process of adipose and cardiomyocyte energy metabolism and in-flammation.Biological evidence shows that SNRK plays a key role in cell signal transduction in various tissues,especially in brown adipose tissue thermogenesis,regulating glucose uptake and insulin resistance,inhibiting NF-κB-mediated in-flammation signaling,and reducing target organ inflammation and fibrosis.It is a potential therapeutic target for obesity,type 2 diabetes and other metabolic diseases.This article reviews the molecular structure,the biological functions,the role and the mechanism of SNRK in energy metabolism and inflammation.
作者
蔡劲薇
李杰
邝建
CAI Jin-Wei;LI Jie;KUANG Jian(Department of Endocrinology,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China;Department of Global Health Research Center,Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences),Guangzhou 510199,China;Department of Endocrinology,Guangdong Provincial People’s Hospital(Guang-dong Academy of Medical Sciences),Guangdong Geriatrics Institute,Guangzhou 510080,China;The Second School of Clinical Medicine,Southern Medical University,Guangzhou 510515,China)
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2021年第5期945-950,共6页
Chinese Journal of Pathophysiology
基金
国家重点研发计划项目课题(No.2018YFC1314104)。
关键词
蔗糖非发酵1相关激酶
糖代谢
脂肪代谢
能量代谢
炎症
Sucrose non-fermentation 1-related kinase
Glucose metabolism
Fat metabolism
Energy metabolism
Inflammation
