摘要
目的初步探讨慢性牙周炎和小气道功能的相关性。方法收集符合标准的受试者135名,其中Ⅰ期、Ⅱ期、Ⅲ期慢性牙周炎各45名。牙周检查包括:牙周探诊深度(PD)、临床附着丧失(CAL)、影像学骨丧失。肺功能仪测定小气道功能,酶联免疫法测定血清炎症介质IL-6、IL-8、TNF-α水平。结果Ⅰ期、Ⅱ期、Ⅲ期慢性牙周炎,血清炎症介质IL-6、IL-8、TNF-α水平存在统计学差异,Ⅰ期、Ⅱ期、Ⅲ期慢性牙周炎小气道功能指标中,呼吸中段流速(FEF25%~75%)百分比、呼吸中期瞬间流速(FEF50%)百分比、呼吸后期瞬间流速(FEF75%)百分比,存在统计学差异。受试者的牙周探诊深度、临床附着丧失、影像学骨丧失与呼吸中段流速(FEF25%~75%)百分比、呼吸中期瞬间流速(FEF50%)百分比、呼吸后期瞬间流速(FEF75%)百分比成负相关。结论慢性牙周炎和小气道功能存在相关性,炎症介质可能作为内在全身因素参与其中。
Objective To preliminarily explore the relationship between chronic periodontitis and small airway function.Methods 135 subjects were recruited in this study and divided into three groups:periodontitis stage I(45),periodontitis stageⅡ(45),and periodontitis stageⅢ(45).Clinical examination indexes included periodontal probing depth(PD),clinical attachment level(CAL)and the level of imaging bone loss.The pulmonary function instrument was used to assess small airway function.Serum inflammatory mediators(IL-6,IL-8 and TNF-α)were determined by enzyme linked immunosorbent assay.Results There were significant differences in the level of serum inflammatory mediators(IL-6,IL-8 and TNF-α)and the percent of FEF25%~75%,FEF50%and FEF75%among different stages of chronic periodontitis.Negative correlations were found between subjects periodontal probing depth,clinical attachment level,imaging bone loss and the percent of FEF25%~75%,FEF50%and FEF75%.Conclusion Correlation is found between chronic periodontitis and small airway function,and mediators may be involved as instrinsic systemic factors.
作者
邱林
舒成军
吴晓东
QIU Lin;SHU Cheng-jun;WU Xiao-dong(Department of Respiratory Medicine,People's Hospital of Yuyao City,Yuyao,Zhejiang 315400,China;Dental Department,People's Hospital of Yuyao City,Yuyao,Zhejiang 315400,China)
出处
《临床肺科杂志》
2021年第6期881-884,共4页
Journal of Clinical Pulmonary Medicine
基金
宁波市第三批科技项目(No.2014C50085)。
关键词
牙周炎
小气道功能
炎症介质
periodontitis
small airway function
inflammatory mediators
