摘要
吴茱萸碱是具有抗肿瘤活性的吲哚喹唑啉类生物碱,其有可能开发成一种治疗肿瘤的药物。研究发现,吴茱萸碱对多种癌细胞的Wnt/β-catenin、mTOR、核因子-κB(NF-κB)、PI3K/AKT、Hippo-YAP、BMP等信号通路有抑制甚至阻断作用,从而干扰细胞分裂分化,提高细胞凋亡比率,并下调了各种癌细胞标志物的表达,如B细胞淋巴瘤2(Bcl-2)、B细胞淋巴瘤超大型(Bcl-XL)、环氧合酶2(COX-2)、Survivin、血管内皮生长因子(VEGF)和基质金属肽酶9(MMP-9),从而对肿瘤细胞不对称分裂、恶性增殖和血管生成产生强有力的抑制作用。本文就吴茱萸碱在消化系统肿瘤中,通过调节Wnt/β-catenin、mTOR、PI3K/AKT、BMP等信号通路,干预细胞分裂分化及凋亡,抑制恶性肿瘤相关标志基因的表达,阻止肿瘤细胞迁移和侵袭等方面进行归纳总结,为吴茱萸碱在日后临床应用和深入研究提供依据。
Evodiamine is an indole quinazoline alkaloid with anti-tumor activity,which may be developed into a drug for the treatment of tumor.It was found that evodiamine could inhibit or even block the signal pathways of Wnt/β-catenin,mTOR,NF-κB,PI3 K/AKT,Hippo-YAP and BMP in many kinds of cancer cells,thus interfering with cell division and differentiation,increasing the rate of apoptosis,and down-regulating the expression of various cancer cell markers.B-cell lymphoma 2(Bcl-2),Bcell lymphoma super-large(Bcl-XL),cyclooxygenase 2(COX-2),survivin,vascular endothelial growth factor(VEGF)and matrix metallopeptidase 9(MMP-9)have a strong inhibitory effect on asymmetric division,malignant proliferation and angiogenesis of tumor cells.This paper summarizes evodiamine in digestive system tumors by regulating Wnt/β-catenin,mTOR,PI3K/AKT,BMP and other signal pathways,interfering with cell division,differentiation and apoptosis,inhibiting the expression of tumor-related marker genes,and preventing tumor cell migration and invasion,so as to provide a basis for the clinical application and further research of evodiamine in the future.
作者
范春娇
黄鹏
黄贵华
邱华
张晓梅
FAN Chun-jiao;HUANG Peng;HUANG Gui-hua;QIU Hua;ZHANG Xiao-mei(Graduate School of Guangxi University of Chinese Medicine,Nanning 530001,China;The Hospital of Guangxi University of Chinese Medicine,Nanning 530023,China)
出处
《海南医学院学报》
CAS
2021年第10期791-796,共6页
Journal of Hainan Medical University
基金
国家自然科学基金项目(81660827)
广西中医药大学名中医黄贵华传承工作室建设项目[桂卫中医发(2017)2号]。
