摘要
动脉粥样硬化疾病是当今人们生命健康的巨大威胁,而血管内介入治疗是最有效的治疗方法之一。金属血管支架是治疗动脉血管疾病的主要手段,但植入血管后会导致支架血栓和支架内再狭窄等问题。生物可吸收血管支架是有望解决支架血栓和支架内再狭窄的新一代血管支架。本文采用3D打印熔融沉积成型技术,分别成型具有不同壁厚、直径,以及采用不同打印填充路径的聚乳酸血管支架和纤维素纳米纤维/聚乳酸复合材料支架,采用平面压缩法和三点弯曲法对其进行体外力学性能测试,获得支架的径向支撑性能和纵向柔顺性能。研究结果表明:相比聚乳酸支架,复合材料支架的径向支撑性能最高提升了47.6%;在相同的支架壁厚和支架直径情况下,复合材料血管支架的纵向柔顺性高于聚乳酸血管支架,提升了20.2%。此外,极差分析结果表明,壁厚对支架体外力学性能影响最大,其次是支架直径,打印填充路径对支架体外力学性能影响较小。本研究的成果为新型生物可吸收降解支架的研制提供了新的思路。
The atherosclerosis is one of the most life-threatening diseases to modern people and percutaneous coronary intervention is an effective method for solving this disease. Currently, bare metal stent(BMS) has been widely used in the clinical practice. But two severe problems may be caused by BMS, i.e. stent thrombosis(ST) and in-stent restenosis(ISR). Bioabsorbable vascular stent(BVS) is one new general vascular stent that may solve the problems caused by BMS because of its good biocompatibility and biodegradability. In this study, the bioabsorbable vascular stents of different stent thickness, stent diameter and infill pattern made by poly(lactic acid) and cellulose nanocomposites were prepared respectively by a fused deposition modeling 3 D printer. The in vitro experimental test for mechanical properties of the vascular stents were performed. Planar compression method for radial support property test and three-point bending method for flexibility of the stents were performed respectively. The test results indicate that in comparison to stents made by neat poly(lactic acid), the radial support property of modified composites stents with larger radius is increased by 47.6% and the flexibility is improved by 20.2% at most. The results of range analyses indicate that the stent thickness has the most significant impact on the in vitro mechanical properties and the infill pattern has less influence on the stent mechanical properties.
作者
贾李涵
李岩
JIA Li-han;LI Yan(School of Aerospace Engineering and Applied Mechanics,Tongji University,Shanghai 200092,China)
出处
《复合材料科学与工程》
CAS
北大核心
2021年第5期61-67,共7页
Composites Science and Engineering
基金
国家自然科学基金(12061130201)。
关键词
3D打印
纤维素纳米复合材料
聚乳酸
血管支架
体外力学性能测试
3D printing
cellulose nanocomposites
vascular stent
poly(lactic acid)
in vitro test for mechanical property
