摘要
利用各种碘代的靛红为底物,与氨基硫脲在水-二氧六环(体积比为5∶1)混合溶剂为反应介质,K_(2)CO_(3)为碱条件下,进行缩合反应,有效合成了一系列结构新型的碘官能团化的[1,2,4]三嗪并[5,6-b]吲哚-3-硫醇类化合物。所合成的目标化合物结构均通过波谱数据和元素分析得以确认。
In this work,a facile synthesis of a series of structurally novel and intriguing iodo-functionalized[1,2,4]triazino[5,6-b]indole-3-thiols has been achieved in good yields through the condensation reaction of various iodo isatins with thiosemicarbazide using H_(2)O-dioxane(VH_(2)O∶V dioxane,5∶1)solvent system as reaction medium in the presence of K_(2)CO_(3) as base.The molecular structures of these synthesized products were confirmed by spectral data and elemental analyses.
作者
王泓雪
纪铭
黄文远
常明琴
WANG Hongxue;JI Ming;HUANG Wenyuan;CHANG Mingqin(College of Chemistry and Materials Engineering,Bohai University,Jinzhou 121000,Liaoning,China;Liaoyang Market Supervision Service Center,Liaoyang 111099,Liaoning,China;Fuxin Institute for Drug Control,Fuxin 123000,Liaoning,China)
出处
《化学研究》
CAS
2021年第2期126-131,共6页
Chemical Research
基金
National Natural Science Foundation of China(21402011)。
