摘要
目的:探讨长期小剂量吸入布地奈德雾化液对闭塞性细支气管炎(bronchiolitis obliterans,BO)患儿临床症状及肺功能的改善情况。方法:收集2015-2019年成都市妇女儿童中心医院儿童呼吸科住院部及呼吸专科门诊确诊的25例BO患儿病例资料,对BO患儿肺功能指标进行随访观察。结果:(1)BO患儿的潮气肺功能主要指标达峰时间比、达峰容积比、小气道功能指标低于健康儿童(P<0.05)。(2)雾化吸入布地奈德治疗3个月,患儿咳嗽喘息次数、用药次数及入院次数无明显改善;6个月后患儿入院次数下降,差异有统计学意义(P<0.05);12个月后咳嗽喘息次数、用药次数、入院次数均下降(P<0.05)。(3)潮气肺功能主要指标在雾化吸入布地奈德治疗3、6、12个月达峰时间比、达峰容积比、TEF_(25)均改善不明显,雾化吸入布地奈德治疗12个月,TEF_(75)、TEF_(50)有改善(P<0.05)。结论:雾化吸入布地奈德溶液长期治疗儿童闭塞性细支气管炎对改善临床症状、潮气肺功能部分指标有一定疗效。
Objective:To probe into the improvement of clinical symptoms and lung function in children with bronchiolitis obliterans(BO)after long-term low-dose atomized inhalation of budesonide solution.Methods:Data of 25 children with BO diagnosed in the inpatient and outpatient department of pediatric respiratory of Chengdu Women’s and Children’s Central Hospital from 2015 to 2019 were collected.The lung function indicators of children with BO were followed up and observed.Results:(1)The main indicators of ventilatory lung function such as the peak-time ratio,peak-volume ratio and small airway function in children with BO were lower than those in healthy children(P<0.05).(2)After 3 months of treatment with atomized inhalation of budesonide solution,there was no significant improvement in the number of cough and wheezing,the number of medication and hospital admission.After 6 months of treatment,the number of hospital admission decreased,with statistically significant difference(P<0.05).After 12 months of treatment,the number of cough and wheezing,the number of medication and hospital admission all decreased(P<0.05).(3)The main indicators of ventilatory lung function showed no significant improvement in the peak time ratio,peak volume ratio and TEF_(25) of atomized inhalation of budesonide treatment in 3,6 and 12 months,and TEF_(75)and TEF_(50)showed improvement after atomized inhalation of budesonide treatment in 12 months(P<0.05).Conclusion:Atomized inhalation of budesonide solution for long-term treatment in children with BO has a certain effect on improving clinical symptoms and some indicators of ventilatory lung function.
作者
谢诚
刘燕茹
艾涛
罗荣华
樊映红
张蕾
苏培媛
Xie Cheng;Liu Yanru;Ai Tao;Luo Ronghua;Fan Yinghong;Zhang Lei;Su Peiyuan(The Affiliated Women’s and Children’s Hospital of Medical College of University of Electronic Science and Technology,Chengdu Women’s and Children’s Central Hospital,Sichuan Chengdu 610051,China)
出处
《儿科药学杂志》
CAS
2021年第5期12-15,共4页
Journal of Pediatric Pharmacy
关键词
布地奈德雾化液
闭塞性细支气管炎
潮气肺功能
atomized inhalation of budesonide solution
bronchiolitis obliterans
ventilatory lung function
