摘要
抗谷氨酸脱羧酶抗体相关脑炎是一种由抗谷氨酸脱羧酶抗体介导的自身免疫性脑炎,属于抗神经元细胞内突触蛋白抗体相关脑炎,临床表现包括僵人综合征、小脑性共济失调、边缘性脑炎、癫痫发作等,常合并多种自身免疫性疾病,极少伴发肿瘤,抗谷氨酸脱羧酶抗体检测对临床诊断较为关键,免疫治疗有助于缓解症状、改善预后。本病发病率低,国内外报道较少,文中拟对该脑炎的研究进展进行综述,希望有助于提高临床医生对该病的认识和诊治水平。
Anti-glutamic acid decarboxylase antibody-associated encephalitis is a kind of autoimmune encephalitis mediated by anti-glutamic acid decarboxylase antibody,which belongs to anti-neuronal intracellular synaptic protein antibody-associated encephalitis.Clinical manifestations include stiff-person syndrome,cerebellar ataxia,limbic encephalitis,seizures,etc.,often associated with a variety of autoimmune diseases,rarely associated with tumors.Detection of anti-glutamic acid decarboxylase antibody is crucial for clinical diagnosis.Immunotherapy helps to relieve symptoms and improve prognosis.The incidence of this disease is low,and there are few reports at home and abroad.This paper intends to review the research on this encephalitis,hoping to improve the clinicians′understanding and the level of diagnosis and treatment of the disease.
作者
闫露露
黄晓雪
唐窈
张爽
吴军
Yan Lulu;Huang Xiaoxue;Tang Yao;Zhang Shuang;Wu Jun(Department of Neurology,First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052,China)
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2021年第4期409-417,共9页
Chinese Journal of Neurology
基金
国家自然科学基金(U1604181)
河南省医学科技攻关计划联合共建项目(LHGJ20190078)
河南省医学教育研究指导性项目(Wjlx2020531)。
关键词
谷氨酸脱羧酶
抗体
自身免疫
脑炎
Glutamate decarboxylase
Antibodies
Autoimmunity
Encephalitis
