摘要
植物源性天然药物因活性成分复杂,多组分发挥作用,成为抗菌药物的研究热点之一。鉴于学者对植物源性天然药物在抗菌作用机制方面的系统性深入研究,将从影响细菌蛋白质合成,改变菌体生物膜通透性及形成,抑制和破坏菌体生物被膜的形成,影响微生物遗传物质以及影响菌体细胞内呼吸作用能量代谢等方面进行综述,以期为植物源性天然药物的后续研究工作和开发新药提供参考。
Plant-derived natural medicine have become one of the hotspots of antibacterial drug research because of their multiple active ingredients and multi-component action. In view of the systematic and in-depth research on the mechanism of antibacterial action of plant-derived natural drugs,the author reviewed the effects of plant-derived natural drugs on bacterial protein synthesis,alteration of bacteriophage biofilm permeability and formation,inhibition and disruption of bacteriophage biofilm formation,influence on microbial genetic material and influence on intracellular respiratory energy metabolism of bacteriophage,with a view to providing reference for the follow-up research work and development of new drugs of plant-derived natural drugs. It was intended to provide a reference for subsequent research and development of new drugs.
作者
周凯仁
李冰
张继瑜
ZHOU Kairen;LI Bing;ZHANG Jiyu(Lanzhou Institute of Animal Husbandry and Pharmaceutical Sciences,Chinese Academy of Agricultural Sciences,Key Laboratory of Veterinary Pharmaceutical Discovery,Ministry of Agriculture and Rural Affairs,Key Laboratory of New Animal Drug Project of Gansu Province,Lanzhou Gansu 730050,China)
出处
《中兽医医药杂志》
CAS
2021年第2期84-88,共5页
Journal of Traditional Chinese Veterinary Medicine
基金
甘肃省科技计划资助——基础研究创新群体(18JR3RA397)
中央级公益性科研院所基本科研业务费专项资金(1610322018002)
国家肉牛牦牛产业技术体系(CARS-37)。
关键词
植物源
天然药物
抑菌
细胞膜
生物膜
Plant-derived
natural medicine
antibacterial
cell membrane
biofilm
