摘要
目的探讨集成磁共振(synthetic magnetic resonance imaging,SyMRI)技术在正常成年人海马定量测量中的应用价值。材料与方法连续收集20~72岁健康成年人139名,男性61名,女性78名。按照年龄分为三组:20~35岁36名,36~55岁72名,56~72岁31名。所有受试者均采用GE SIGNA Pioneer 3.0 T MRI进行头颅检查。扫描序列包括3D T1WI毁损梯度回波序列(3D T1WI spoiled gradient recalled echo,3D T1WI-SPGR)和SyMRI序列,应用SyMRI后处理软件对全脑进行自动配准及数值提取。不同侧别间的海马T1、T2及质子密度(proton density,PD)值采用配对t检验,不同性别分组间的海马T1、T2及PD值采用两独立样本Mann-Whitney U检验,不同年龄组间采用方差分析,不同年龄分组内两两比较采用LSD法。结果139名健康成年人的T1、T2、PD均值分别分别是(1258.43±110.59)ms、(105.88±16.05)ms、(74.71±1.52)pu,T1值、T2值、PD值的范围依次是(1070.16~1725.59)ms、(86.43~190.71)ms、(70.72~80.21)pu。不同侧别海马T1和PD值差异均有统计学意义(P值均<0.05),且T1和PD值左侧均大于右侧。而不同侧别海马T2值以及不同性别间的T1、T2和PD值之间没有统计学差异(P>0.05)。T1、T2及PD值不同年龄组之间差别有统计学意义(P<0.05),20~35岁组和36~55岁组与56~72岁组之间差异有统计学意义(P<0.05),20~35岁组与36~55岁组之间差异无统计学意义(P>0.05)。结论集成磁共振技术能够提供不同年龄及性别正常成年人海马定量参考值,为海马相关疾病的早期诊断提供重要依据。
Objective:To explore the application value of synthetic magnetic resonance technology(SyMRI)in the quantitative measurement of the hippocampus in normal adults.Materials and Methods:A total of 139 healthy adults aged 20 to 72 were collected,including 61 males and 78 females.According to age,they were divided into three groups(20—35 years old)36 cases,(36—55 years old)72 cases,(56—72 years old)31 cases.All subjects were examined with GE SIGNA Pioneer 3.0 T MRI.The scanning sequence included 3D-TWI damage gradient echo sequence(3D T1WI-SPGR)and SyMRI sequence.The whole brain was automatically registered and extracted by SyMRI post-processing software.The hippocampal T1,T2 and proton density(PD)values of both sides were tested by paired t-test.The hippocampal T1,T2 and PD values of different gender groups were tested by two independent samples Mann-Whitney U test,the analysis of variance was used among different age groups,and the pairwise comparison among different age groups was performed by LSD method.Results:The mean values of T1,T2 and PD in 139 healthy adults were(1258.43±110.59)ms,(105.88±16.05)ms,(74.71±1.52)pu,respectively.The range of T1 value,T2 value,and PD value were(1070.16—1725.59)ms,(86.43—190.71)ms,(70.72—80.21)pu.There were significant differences in T1 and PD values of hippocampus in different sides(P<0.05),and the values of T1 and PD on the left side were higher than those on the right side.There was no significant difference in T2 values between different sides of hippocampus and T1,T2 and PD values between sexes(P>0.05).There were significant differences in T1,T2 and PD values among different age groups(P<0.05).There were significant differences between 20 to 35 years old group,36 to 55 years old group and 56 to 72 years old group(P<0.05).There was no significant difference between 20 to 35 years old group and 36 to 55 years old group(P>0.05).Conclusions:SyMRI can provide quantitative reference values of hippocampus in normal adults of different ages and genders,and provide an im
作者
吴文浩
俞文君
朱诞恬
钱龙
李绍林
WU Wenhao;YU Wenjun;ZHU Dantian;QIAN Long;LI Shaolin(Department of Radiology,Fifth Affiliated Hospital,Sun Yat-Sen University,Zhuhai 519000,China;MR Research,GE Healthcare,Beijing 100000,China)
出处
《磁共振成像》
CAS
CSCD
北大核心
2021年第5期55-59,共5页
Chinese Journal of Magnetic Resonance Imaging
关键词
年龄
性别
海马
集成磁共振成像
定量
aging
sex
hippocampus
synthetic magnetic resonance imaging
quantification
