摘要
目的探索卒中后失语(PSA)患者局部脑神经活动在不同频段的特征及西方失语成套测试(WAB)评分与特定频段的关系。方法2015年3月至2018年5月,招募本院PSA患者15例(患者组)和年龄、性别、受教育程度等匹配的健康成年人15例(对照组),采用WAB测试;采集静息态功能性磁共振成像(rs-fMRI),计算低频振幅(ALFF)和比率低频振幅(fALFF)在0.01~0.08 Hz、0.027~0.073 Hz、0.01~0.027 Hz的变化;提取不同频段差异脑区ALFF和fALFF与患者组WAB评分进行相关性分析。结果在0.01~0.08 Hz,患者组右侧中央前回ALFF增高。在0.027~0.073 Hz,患者组右侧中央前回ALFF增高;患者组右侧小脑Crus2区fALFF减弱,右侧小脑Crus2区fALFF与WAB信息量(r=-0.576,P=0.025)、听理解(r=-0.658,P=0.008)、复述评分(r=-0.616,P=0.014)和失语商(r=-0.611,P=0.016)呈负相关;在0.01~0.027 Hz,患者组左顶下缘角回fALFF减弱,左顶下缘角回fALFF与信息量评分(r=0.538,P=0.039)和失语商(r=0.526,P=0.044)呈正相关。结论PSA患者的静息态fALFF异常具有频率依赖性,不同频段脑fALFF存在频段特异性神经功能改变。
Objective To explore the characteristics of local brain neural activity in post stroke aphasia(PSA)patients in different frequency bands and the relationship between Western Aphasia Battery(WAB)scores and specific frequency bands.Methods From March,2015 to May,2018,15 PSA patients,and 15 healthy adults as controls matched for age,gender and education were recruited.They were assessed with WAB and scaned with resting-state functional magnetic resonance imaging.The amplitude of low-frequency fluctuation(ALFF)and fractional amplitude of low-frequency fluctuation(fALFF)on the frequency bands of 0.01-0.08 Hz,0.027-0.073 Hz,and 0.01-0.027 Hz were calculated.The ALFF and fALFF in different frequency bands were extracted and the correlation with the WAB scores in the patients were analyzed.Results On 0.01-0.08 Hz,ALFF increased in the right precentral gyrus in the patients.On 0.027-0.073 Hz,ALFF increased values in the right precentral gyrus,and fALFF decreased in the right cerebellar Crus2 region;fALFF in the right cerebellar Crus2 region negatively correlated with the scores of information content(r=-0.576,P=0.025),auditory comprehension(r=-0.658,P=0.008),repetition(r=-0.616,P=0.014)and aphasia quotient(r=-0.611,P=0.016)of WAB.On 0.01-0.027 Hz,the fALFF decreased in the left inferior parietal limbic gyrus,and positively correlated with the scores of information content(r=0.538,P=0.039)and aphasia quotient(r=0.526,P=0.044).Conclusion Resting-state fALFF abnormalities in PSA patients are frequency-dependent,which associate with some frequency-specific neurofunctional alterations.
作者
李晓琳
徐敏杰
曹云
张丹莉
舒鑫
李昌明
周雨帆
谭逸海
谭中建
常静玲
LI Xiao-lin;XU Min-jie;CAO Yun;ZHANG Dan-li;SHU Xin;LI Chang-ming;ZHOU Yu-fan;TAN Yi-hai;TAN Zhong-jian;CHANG Jing-ling(Department of Neurology,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)
出处
《中国康复理论与实践》
CSCD
北大核心
2021年第5期497-503,共7页
Chinese Journal of Rehabilitation Theory and Practice
基金
北京市自然科学基金重点项目(No.7181005)
国家自然科学基金面上项目(No.81973790)
北京中医药大学科研创新团队项目(No.2019-JYB-TD003)。
关键词
卒中后失语
低频振幅
比率低频振幅
亚频段分析
post stroke aphasia
amplitude of low-frequency fluctuation
fractional amplitude of low-frequency fluctuation
frequency-dependent alterations
