摘要
目的探讨术前新辅助化疗(NACT)对局部晚期宫颈癌的治疗效果。方法抽取2018年2月至2020年3月山西省人民医院收治的局部晚期宫颈癌女性患者200例,依据治疗方案将其分为两组。对照组100例给予宫颈癌根治术治疗,观察组100例在宫颈癌根治术前应用多西他赛和奈达铂方案行NACT。回顾性分析NACT的辅助疗效,比较两组相关指标及不良反应。结果术前给予NACT的观察组临床有效率为94%(94/100),肿瘤长径由术前的(10.33±3.04)cm缩小至(5.33±2.19)cm,P<0.05。观察组手术时间、出血量少于对照组(t=9.522、7.843、1.055,P<0.05)。两组清扫淋巴结数、阴道切除长度、术后化疗次数比较,t=2.496、1.221、1.055,P>0.05。两组化疗不良反应如胃肠道反应、神经毒性、骨髓抑制发生率比较,t=1.750、0.690、0.050,P>0.05。结论局部晚期宫颈癌行根治术前应用NACT可缩小肿瘤体积,减少手术出血量、手术时间,且不增加化疗不良反应。
Objective To investigate the effect of neoadjuvant chemotherapy(NACT)before operation in the treatment of locally advanced cervical cancer(LACC).Methods A total of 200 female patients with LACC admitted to Shanxi Provincial People’s Hospital from February 2018 to March 2020 were divided into two groups according to the treatment plan.One hundred patients in the control group were treated with radical cervical cancer,and 100 patients in the observation group were treated with docetaxel and nedaplatin before radical cervical cancer surgery.One hundred patients in the control group were treated with radical cervical cancer,and 100 patients in the observation group were treated with taxotere and nedaplatin before radical cervical cancer surgery.The adjuvant efficacy of NACT was analyzed retrospectively,and the related indicators and adverse reactions of the two groups were compared.Results The clinical effective rate of the observation group who was given NACT before operation was 94%(94/100).The long diameter of the tumor was reduced from(10.33±3.04)cm before operation to(5.33±2.19)cm,P<0.05.The operation time and blood loss in the observation group were less than those in the control group(t=9.522,7.843,1.055,P<0.05).The number of lymph nodes,the length of vaginal resection,and the number of postoperative chemotherapy were compared between the two groups,t=2.496,1.221,1.005,P>0.05.The incidence of adverse chemotherapy reactions,such as gastrointestinal reactions,neurotoxicity,and bone marrow suppression were compared between the two groups,t=1.750,0.690,0.050,P>0.05.Conclusions The application of NACT before radical resection of locally advanced cervical cancer can reduce tumor volume,reduce surgical blood loss and operation time,and does not increase the adverse reactions of chemotherapy.
作者
李慧
Li Hui(Department of Gynecology,Shanxi Provincial People's Hospital,Taiyuan 030001,China)
出处
《中国实用医刊》
2021年第6期31-33,共3页
Chinese Journal of Practical Medicine
关键词
宫颈癌
新辅助化疗
多西他赛
Cervical cancer
Neoadjuvant chemotherapy
Taxotere
