摘要
目的:从性别、尿蛋白、高血压和肾功能等方面探讨IgA肾病患者的临床特点。方法:回顾性分析2013年6月-2018年1月在北海市第二人民医院及医联体单位治疗的98例IgA肾病患者的临床资料。所有患者均经肾穿病理检查明确诊断,均常规检测24 h尿蛋白、白蛋白(ALB)、尿酸、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)和高密度脂蛋白胆固醇(HDL-C)。分别按尿蛋白、性别、高血压及肾功能对所有IgA肾病患者进行分组,将各组的临床指标进行比较。结果:男性组大量蛋白尿的比例高于女性组,白蛋白及尿酸水平均高于女性组,而HDL水平低于女性组,差异均有统计学意义(P<0.05);两组的年龄、高血压、肾功能异常、尿蛋白、肌酐、TC、TG、LDL-C比较,差异均无统计学意义(P>0.05)。大量蛋白尿组患者高血压和肾功能异常的发病率均高于非大量蛋白尿组,肌酐、TC、LDL-C及TG水平均高于非大量蛋白尿组,而白蛋白水平低于非大量蛋白尿组,差异均有统计学意义(P<0.05);两组患者的年龄、尿酸及HDL-C比较,差异均无统计学意义(P>0.05)。高血压组的年龄、尿蛋白、肌酐、尿酸及TG均高于无高血压组,差异均有统计学意义(P<0.05);两组患者的白蛋白、TC、LDL-C及HDL-C水平比较,差异均无统计学意义(P>0.05)。肾功能异常组的尿蛋白、尿酸及TG水平均高于肾功能正常组,差异均有统计学意义(P<0.01);两组患者的年龄、白蛋白、TC、LDL-C及HDL-C比较,差异均无统计学意义(P>0.05)。结论:在IgA肾病患者中,男性大量蛋白尿的比例高于女性;大量蛋白尿患者的高血压和肾功能异常的发病率均高于非大量蛋白尿;合并高血压患者的年龄、尿蛋白、肌酐、尿酸和TG均高于无高血压;肾功能异常患者的尿蛋白、尿酸及TG水平均高于肾功能正常。
Objective:To explore the clinical characteristics of patients with IgA nephropathy from the aspects of gender,urinary protein,hypertension and renal function.Method:The clinical data of 98 patients with IgA nephropathy who were treated in the Second People’s Hospital of Beihai City and the medical association unit from June 2013 to January 2018 were retrospectively analyzed.All patients were diagnosed by renal biopsy,and 24 h urinary protein,albumin(ALB),uric acid,total cholesterol(TC),low density lipoprotein cholesterin(LDL-C),triglyceride(TG)and high density lipoprotein cholesterin(HDL-C)were detected routinely.All patients with IgA nephropathy were divided into groups according to urinary protein,gender,hypertension and renal function,and the clinical indexes of each group were compared.Result:The proportion of proteinuria in male group was higher than that in female group,the levels of ALB and uric acid were higher than those in female group,while the level of HDL-C was lower than that in female group,the differences were statistically significant(P<0.05).There were no significant differences in age,hypertension,renal dysfunction,urinary protein,creatinine,TC,TG and LDL-C between the two groups(P>0.05).The incidences of hypertension and renal dysfunction in the group with large amounts of proteinuria were higher than those in the group without large amounts of proteinuria,the levels of creatinine,TC,LDL-C and TG in the group with large amounts of proteinuria were higher than those in the group without large amounts of proteinuria,while the level of ALB was lower than that in the group without large amounts of proteinuria,the differences were statistically significant(P<0.05).There were no significant differences in age,uric acid and HDL-C between two groups(P>0.05).The mean age,urinary protein,creatinine,uric acid and TG of the hypertensive group were higher than those of the non-hypertensive group,the differences were statistically significant(P<0.05).Comparison of ALB,TC,LDL-C and HDL-C levels between the
作者
潘庆登
黄冠美
叶祖兰
曾春
宁万如
PAN Qingdeng;HUANG Guanmei;YE Zulan;ZENG Chun;NING Wanru(The Second People’s Hospital of Beihai City,Beihai 536000,China;不详)
出处
《中国医学创新》
CAS
2021年第11期133-137,共5页
Medical Innovation of China
基金
北海巿科学研究与技术开发项目(北科合201777033)。
关键词
IGA肾病
尿蛋白
高血压
肾功能
血脂
IgA nephropathy
Urinary protein
Hypertension
Renal function
Serum lipids
