摘要
目的:探讨金银花液联合鼻腔冲洗治疗鼻咽癌放疗后鼻窦炎的临床疗效。方法:选择嘉兴市第一医院2018年2月至2020年2月收治的鼻咽癌放疗后鼻窦炎患者82例为研究对象,按随机数字表法分为观察组和对照组,每组41例。对照组采取0.9%氯化钠注射液冲洗鼻腔,每天1次;观察组在对照组基础上采取金银花液雾化吸入,每天1次;两组连续治疗4周。比较两组视觉模拟量表(VAS)和Lund-Kennedy内镜黏膜形态评分系统评分、纤毛传输速率、临床疗效以及不良反应发生情况。结果:观察组治疗后鼻塞评分[(0.82±0.10)分]、黏性或脓性鼻涕评分[(1.88±0.25)分]、嗅觉障碍评分[(1.12±0.15)分]、头面痛评分[(0.40±0.06)分]和鼻内镜Lund-Kennedy评分[(2.03±0.26)分]均明显低于对照组[(1.94±0.26)分、(2.93±0.37)分、(1.73±0.25)分、(0.62±0.09)分、(4.07±0.47)分],纤毛传输速率[(4.71±0.56)mm/min]明显高于对照组[(3.94±0.51)mm/min](t=9.156、15.056、13.397、13.023、9.156、15.056,均P<0.01)。观察组总有效率为97.56%(40/41),明显高于对照组的80.49%(33/41)(χ^(2)=4.493,P<0.05)。对照组有1例患者并发鼻出血,观察组未发生任何不良反应。结论:金银花液联合鼻腔冲洗治疗鼻咽癌放疗后鼻窦炎的疗效明显,可显著改善患者的症状体征,且安全性好。
Objective To investigate the clinical efficacy of honeysuckle extraction liquid combined with nasal irrigation in the treatment of nasosinusitis after radiotherapy of nasopharyngeal carcinoma.Methods Eighty-two patients with nasosinusitis post-radiotherapy who received treatment between February 2018 and February 2020 in the First Hospital of Jiaxing were included in this study.They were randomly assigned to receive either nasal irrigation with 0.9%sodium chloride injection(control group,n=41)or atomization treatment with honeysuckle extract liquid plus nasal irrigation with 0.9%sodium chloride injection(observation group,n=41),once daily for 4 successive weeks.Visual Analogue Scale(VAS)and nasal endoscopic Lund-Kennedy(LK)score,ciliary transport rate,clinical efficacy and adverse reactions were compared between the control and observation groups.Results After treatment,the nasal congestion score[(0.82±0.10)points],viscous or purulent nasal discharge score[(1.88±0.25)points],olfactory dysfunction score[(1.12±0.15)points],head and face pain score[(0.40±0.06)points]and nasal endoscopic Lund-Kennedy score[(2.03±0.26)points]in the observation group were significantly lower than those in the control group[(1.94±0.26)points,(2.93±0.37)points,(1.73±0.25)points,(0.62±0.09)points,(4.07±0.47)points,respectively,t=9.156,15.056,13.397,13.023,9.156,all P<0.01].The ciliary transport rate in the observation group[(4.71±0.56)mm/min]was significantly higher than that in the control group[(3.94±0.51)mm/min,t=15.056,P<0.01].Total effective rate in the observation group was 97.56%(40/41),which was significantly higher than 80.49%(33/41)in the control group(χ^(2)=4.493,P<0.05).In the control group,one patient had epistaxis,and no adverse reaction was observed in the observation group.Conclusion Honeysuckle extraction liquid combined with nasal irrigation with 0.9%sodium chloride injection is effective in the treatment of nasosinusitis after radiotherapy for nasopharyngeal carcinoma,can greatly improve the symptoms and si
作者
周亚娟
李侠
Zhou Yajuan;Li Xia(Department of Oncology,The First Hospital of Jiaxing,Jiaxing 314000,Zhejiang Province,China)
出处
《中国基层医药》
CAS
2021年第4期518-522,共5页
Chinese Journal of Primary Medicine and Pharmacy
基金
浙江省嘉兴市科技局(自主研发)项目(2018AD32052)。
关键词
鼻咽癌
金银花
鼻腔冲洗
鼻窦炎
放射疗法
雾化吸入
内镜
安全性
Nasopharyngeal carcinoma
Jinyinhua
Nasal douching
Radiotherapy
radiation therapy
atomization inhalation
endoscopy
Safety
