摘要
目的分析强化营养联合双歧杆菌对腹型过敏性紫癜(AP)患儿症状、肠道功能及血清转铁蛋白(TRF)、前清蛋白(PA)等营养指标的影响。方法选取2017年6月至2018年11月在该院接受治疗的腹型AP患儿117例为研究对象,根据治疗方案分为对照组57例和观察组60例。两组患儿均进行常规治疗。对照组给予丙氨酰-谷氨酰胺治疗,观察组于对照组治疗的基础上,联合双歧杆菌三联活菌散治疗。比较两组患儿治疗期间症状反复比例、住院天数、静脉激素使用比例及时间、体质量情况,禁食>5 d的比例;记录两组治疗前后血清内毒素(LPS)、二胺氧化酶(DAO)、D-乳酸(D-L)水平,检测视黄醇结合蛋白(RBP)、TRF、PA、血红蛋白(Hb)和血清清蛋白(ALB)水平,16SrDNA荧光定量PCR技术检测治疗前后粪便中双歧杆菌和大肠杆菌数量、双歧杆菌/大肠杆菌比值(B/E值)。结果治疗前,两组患儿血清D-L、DAO、LPS、RBP、TRF、PA、ALB水平、双歧杆菌、大肠杆菌及B/E值比较,差异无统计学意义(P>0.05)。治疗后,住院天数、腹痛天数、皮疹天数、静脉激素使用时间、静脉激素使用比例和体质量降低比例较对照组明显降低,差异有统计学意义(P<0.05);两组D-L、DAO和LPS水平均降低,观察组D-L和DAO水平明显低于对照组,差异有统计学意义(P<0.05);观察组血清RBP、TRF、PA水平较对照组明显升高,差异有统计学意义(P<0.05);观察组双歧杆菌、大肠杆菌数量及B/E值均较对照组明显升高,差异有统计学意义(P<0.05)。结论强化营养联合双歧杆菌较单独强化营养更能改善腹型AP患儿症状,保护肠道黏膜屏障功能,获得更好的营养支持。
Objective To analyze the effect of intensive nutrition combined with Bifidobacterium on symptoms,intestinal function,serum transferrin(TRF),prealbumin(PA)and other nutritional indicators in children with abdominal allergic purpura(AP).Methods A total of 107 children with abdominal AP who were treated in General Hospital of North China Petroleum Administration from June 2017 to November 2018 were divided into control group(n=57)and observation group(n=60)according to therapy methods.Children in both groups were treated with abnormal treatment.Children in control group received alanyl-glutamine fortified nutrition,and children in observation group received extra Bifidobacterium triple viable powder on the basis of control group.The proportion of recurrence of symptoms,length of hospital stay,frequency and duration of intravenous hormone use,weight and the proportion of fasting for more than 5 days of the two groups during the treatment period were compared.Lipopolysaccharide(LPS),diamine oxidase(DAO),D-lactic acid(D-L)levels and intravenous retinol-binding protein(RBP),TRF,PA,hemoglobin(Hb)and serum albumin(ALB)levels were recorded before and after treatment,16SrDNA fluorescence quantitative PCR technology was used to detect the number of Bifidobacterium,E.coli,the ratio of Bifidobacterium/E.Coli(B/E)in the feces before and after treatment.Results Before treatment,there was no significant difference on serum D-L,DAO,LPS,RBP,TRF,PA,ALB levels,Bifidobacterium,E.coli and B/E values(P>0.05).After treatment,the length of hospital stay,the duration of abdominal pain,the duration of rash and intravenous hormone use,the proportion of intravenous hormone use and the weight loss were significantly lower than those of control group(P<0.05).The levels of D-L,DAO and LPS in the two groups reduced,the levels of D-L and DAO in observation group were significantly lower than those of control group(P<0.05).The serum RBP,TRF and PA levels in observation group were significant higher than those of control group(P<0.05),the number of
作者
刘燕
刘红伟
刘艳静
LIU Yan;LIU Hongwei;LIU Yanjing(Department of Clinical Nutrition,General Hospital of North China Petroleum Administration,Changzhou,Hebei 062552,China;Department of Pediatrics,General Hospital of North China Petroleum Administration,Changzhou,Hebei 062552,China;Department of Nursing,General Hospital of North China Petroleum Administration,Changzhou,Hebei 062552,China)
出处
《国际检验医学杂志》
CAS
2021年第10期1259-1262,共4页
International Journal of Laboratory Medicine
关键词
腹型过敏性紫癜
强化营养
双歧杆菌
肠道功能
营养状态
abdominal allergic purpura
intensive nutrition
Bifidobacterium
intestinal function
nutritional status
