摘要
目的 分析低血糖生成指数饮食联合抗精神病药物治疗精神分裂症患者的临床效果.方法 选择2019年9月至2020年8月在上海市黄浦区精神卫生中心住院的80例精神分裂症患者作为研究对象.采用随机数字表法分为对照组和观察组,各40例.观察组在原有抗精神病药物治疗的基础上给予低血糖生成指数饮食治疗,对照组则在原有抗精神病药物治疗的基础上给予普通病房饮食.比较两组的治疗效果.结果 饮食治疗后,观察组的阳性与阴性症状量表(PANSS)总分及其阳性症状因子分、阴性症状因子分和一般精神病理症状因子分均呈下降趋势.经重复测量方差分析,PANSS总分显示组间主效应、时间主效应、时间和分组交互效应的差异均有统计学意义(F1=6.783,P1=0.011;F2=41.378,P2<0.001;F3=41.378,P3<0.001);阳性症状因子分显示时间主效应及时间和分组交互效应的差异有统计学意义(F1=10.302,P1<0.001;F2=6.483,P3<0.001),组间主效应差异无统计学意义(F=0.384,P=0.537);阴性症状因子分显示组间主效应及时间和分组交互效应的差异有统计学意义(F1=4.655,P1=0.035;F2=37.087,P3<0.001),时间主效应差异无统计学意义(F=2.594,P=0.054);一般精神病理症状因子分显示时间主效应及时间和分组交互效应差异有统计学意义(F1=36.177,P1<0.001;F2=37.087,P2<0.001),组间主效应差异无统计学意义(F=3.670,P=0.071).从第8周末开始,PANSS总分、阴性症状因子分和一般精神病理症状因子分的组间差异具有统计学意义,第8周末分别为(t1=3.507,P1=0.001;t2=2.126,P2=0.037;t3=2.839,P3=0.006),第12周末分别为(t1=4.337,P1=0.001;t2=3.201,P2=0.002;t3=3.000,P3=0.004).从第4周末开始,观察组的PANSS总分、阳性症状因子分和一般精神病理症状因子分与治疗前比较具有统计学意义,第4周末分别为(t1=7.481;t2=3.616;t3=5.430,P<0.05),第8周末分别为(t1=7.649;t2=4.572;t3=7.531,P<0.05),第12周末分别为(t1=7.564;t2=4.869;t3
Objective To analyze the clinical effect of low glycemic index diet combined with antipsychotics in the treatment of schizophrenia.Methods From September 2019 to August 2020,80 schizophrenic patients who were hospitalized in Shanghai Huangpu Mental Health Center were selected as the research objects.They were divided into control group and observation group with 40 cases in each group by random number table method.The observation group was given low glycemic index diet therapy on the basis of the original antipsychotic drug treatment,while the control group was given ordinary ward diet on the basis of the original antipsychotic drug treatment.The therapeutic effects of the two groups were compared.Results After dietary treatment,the total scores of the Positive and negative symptom scale(PANSS)and the scores of positive symptom factors,negative symptom factors and general psychopathological symptom factors of the observation group showed a downward trend.After repeated measures analysis of variance,the PANSS total score showed that the differences in the main effects,time main effects,time and group interaction effects were statistically significant(F1=6.783,P1=0.011;F2=41.378,P2<0.001;F3=41.378,P3<0.001);positive symptom factor scores show that the main effect of time and the difference between time and group interaction are statistically significant(F1=10.302,P1<0.001;F2=6.483,P3<0.001),the main effect difference between groups No statistical significance(F=0.384,P=0.537);negative symptom factor scores showed that the differences in the main effects and the interaction effects of time and grouping between groups were statistically significan(t F1=4.655,P1=0.035;F2=37.087,P3<0.001),the main effect of time was not statistically significant(F=2.594,P=0.054);general psychopathological symptom factors showed that the main effect of time and the interaction effect between time and group were statistically significant(F1=36.177,P1<0.001;F2=37.087,P2<0.001),the main effect difference between the groups was not statisti
作者
冷晓赟
沈弈菲
岳英
李志行
王开颜
王纪文
王继军
Leng Xiaoyun;Shen Yifei;Yue Ying;Li Zhixing;Wang Kaiyan;Wang Jiwen;Wang Jijun(Department of Psychiatry,Shanghai Mental Health Center,Shanghai JiaoTong University School of Medicine,Shanghai 200030,China;Department of Nutrition,Shanghai Huangpu Mental Health Center,Shanghai 200023,China;Department of Psychiatry,Shanghai Huangpu Mental Health Center,Shanghai 200023,China;Department of Neurology,Huashan Hospital Affiliated to Fudan University,Shanghai 200040,China;Department of Neurology,Shanghai Children’s Medical Center Affiliated to Shanghai Jiao Tong University,Shanghai 200127,China)
出处
《神经疾病与精神卫生》
2021年第3期191-196,共6页
Journal of Neuroscience and Mental Health
基金
上海市黄浦区卫生健康系统科研项目(HKM201919)。
