摘要
目的研究数字减影血管造影(DSA)引导下肝动脉化疗栓塞(TACE)法治疗肝细胞癌(HCC)的疗效及对患者血管生成和生存率的影响。方法选择2017年2月至2018年2月在空军军医大学唐都医院就诊的80例HCC患者为研究对象,按随机数表法分为观察组和对照组,每组40例。对照组患者采用常规化疗,观察组患者在对照组治疗基础上采用DSA引导TACE疗法,两组均治疗3个月,比较两组患者的治疗效果,以及治疗前后的血管内皮生长因子(VEGF)、基质金属蛋白酶9(MMP-9)、谷草转氨酶(AST)和谷丙转氨酶(ALT)水平;同时比较两组患者治疗后6个月、1年、2年的生存率和治疗期间的不良反应发生情况。结果观察组患者的治疗总有效率为85.0%,明显高于对照组的65.0%,差异有统计学意义(P<0.05);观察组患者治疗后的VEGF、MMP-9水平分别为(138.70±19.2)pg/mL、(68.33±8.76)pg/mL,明显低于对照组的(224.85±23.70)pg/mL、(86.52±9.14)pg/mL,差异均有统计学意义(P<0.05);观察组患者治疗后的ALT、AST水平分别为(107.25±15.83)U/L、(96.17±13.86)U/L,明显低于对照组的(129.50±16.56)U/L、(124.81±14.26)U/L,差异均有统计学意义(P<0.05);观察组患者术后1年、2年生存率分别为87.5%、77.5%,明显高于对照组的67.5%、55.0%,差异均有统计学意义(P<0.05);治疗期间观察组患者的总不良反应发生率为35.0%,明显低于对照组的50.0%,差异有统计学意义(P<0.05)。结论DSA引导下行TACE介入法治疗HCC疗效较好,其对患者的血管生成有抑制作用,且对肝损伤相对较小,预后较好。
Objective To study the efficacy of digital subtraction angiography(DSA)-guided transcatheter arterial chemoembolization(TACE)in the treatment of hepatocellular carcinoma(HCC)and its influence on angiogenesis and survival rate in HCC patients.Methods Eighty HCC patients who visited the Air Force Medical University Tangdu Hospital from February 2017 to February 2018 were selected as the research objects.They were randomly divided into observation group and control group,with 40 patients in each group.Patients in the control group were treated with conventional chemotherapy,while patients in the observation group were treated with DSA-guided TACE on the basis of the treatment in the control group.Both groups were treated for 3 months.The therapeutic effect of the two groups and the levels of vascular endothelial growth factor(VEGF),matrix metalloproteinase-9(MMP-9),aspartate aminotransferase(AST),and alanine aminotransferase(ALT)before and after treatment were compared.At the same time,the survival rates of 6 months,1 year and 2 years after treatment and the occurrence of adverse reactions during intervention were compared between the two groups.Results The total effective rate was 85.0%in the observation group and 65.0%in the control group,and the difference was statistically significant(P<0.05).The levels of VEGF and MMP-9 were(138.70±19.2)pg/mL and(68.33±8.76)pg/mL,respectively,significantly lower than(224.85±23.70)pg/mL and(86.52±9.14)pg/mL in the control group(P<0.05).The levels of ALT and AST in the observation group were(107.25±15.83)U/L and(96.17±13.86)U/L,respectively,significantly lower than(129.50±16.56)U/L and(124.81±14.26)U/L in the control group(P<0.05).The 1-and 2-year survival rates were 87.5%and 77.5%,respectively,which were significantly higher than 67.5%and 55.0%in the control group(P<0.05).The total incidence of adverse reactions during the intervention period was 35.0%,which was significantly lower than 50.0%in the control group(P<0.05).Conclusion DSA-guided TACE interventional therapy i
作者
刘佩肖
裴海峰
李亚洲
卫飞鹏
LIU Pei-xiao;PEI Hai-feng;LI Ya-zhou;WEI Fei-peng(Department of Cardiopulmonary Rehabilitation,Xi’an International Medical Center Hospital,Xi'an 710038,Shaanxi,CHINA;Department of Cardiovascular Medicine,General Hospital of the Western Theater Command of the Chinese People's Liberation Army,Chengdu 610083,Sichuan,CHINA;Department of Interventional Pain,Baoji High-tech Hospital,Baoji 721000,Shaanxi,CHINA;Interventional Radiography Department,the Air Force Medical University Tangdu Hospital,Xi'an 710038,Shaanxi,CHINA)
出处
《海南医学》
CAS
2021年第9期1128-1132,共5页
Hainan Medical Journal
关键词
肝细胞癌
数字减影血管造影
肝动脉化疗栓塞
疗效
血管生成
生存率
Hepatocellular carcinoma
Digital subtraction angiography
Transcatheter arterial chemoembolization
Efficacy
Angiogenesis
Survival rate
