摘要
目的探讨拉莫三嗪联合丙戊酸钠治疗小儿癫痫的疗效及安全性。方法收治我院于2018年1月至2020年1月就诊的60例小儿癫痫患儿为观察对象,以计算机数字随机分配原则将其分为对照组与观察组,每组中患儿分别为30例,对照组患儿应用丙戊酸钠药物治疗,观察组患儿则应用拉莫三嗪联合丙戊酸钠治疗,对比两组患儿治疗后的临床疗效及用药安全性。结果比较对照组患儿治疗后总有效率73.3%,观察组患儿治疗后总有效率90.0%明显更高,P<0.05,组间相比差异有统计学意义。两组患儿治疗后不良反应发生率对比差异不明显(P>0.05)无统计学意义;治疗前患者超敏C反应蛋白、Hcy、TNF-α水平无明显差异,治疗后观察组患者超敏C反应蛋白、Hcy、TNF-α水平显著优于对照组,P<0.05,有统计学意义。结论将拉莫三嗪联合丙戊酸钠用药方案用于小儿癫痫的临床治疗中,可提高药物治疗效果,并确保用药安全性,减少不良反应发生,可在临床普及应用。
Objective To investigate the efficacy and safety of lamotrigine combined with sodium valproate in the treatment of children with epilepsy.Methods 60 cases of children with epilepsy in our hospital from January 2018 to January 2020 were selected as the observation objects,and they were divided into control group and observation group according to the principle of computer digital random distribution,with 30 cases in each group.The control group was treated with sodium valproate,while the observation group was treated with lamotrigine combined with sodium valproate drug safety.Results The total effective rate was 73.3%in the control group,and 90.0%in the observation group,which was significantly higher than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Lamotrigine combined with sodium valproate in the clinical treatment of pediatric epilepsy can improve the effect of drug treatment,ensure the safety of drug use,reduce the occurrence of adverse reactions,and can be widely used in clinical practice.
作者
李国伟
LI Guo-wei(Foshan Maternal and Child Health Care Hospital,Foshan,Guangdong 528000)
出处
《智慧健康》
2021年第2期156-158,共3页
Smart Healthcare
