摘要
目的分析替格瑞洛联合利伐沙班对不稳定型心绞痛合并2型糖尿病患者的抗炎作用。方法选取自2019年1月至2019年12月于本院治疗的不稳定型心绞痛合并2型糖尿病患者60例为观察组;另选取20例健康志愿者为对照组,对比分析观察组患者治疗前后与对照组sCD40L、IL-6、hsCRP、外周血样本CEC、生活质量的差别,分析观察组患者不良反应发生率。结果观察组患者治疗前与对照组sCD40L、IL-6、hsCRP、外周血样本CEC、生活质量对比存在显著差距,对比有统计学意义(P<0.05),观察组患者治疗后与对照组sCD40L、IL-6、hsCRP、外周血样本CEC、生活质量对比差距不大,不存在统计学意义(P>0.05);观察组患者药物治疗后心脑血管疾病以及脏器出血发生的几率为8.3%。结论对不稳定型心绞痛合并2型糖尿病患者采用替格瑞洛联合利伐沙班进行治疗,可有效改善患者血清中sCD40L、IL-6、hsCRP水平,降低患者外周血样本CEC,有利于提高生活质量。
Objective To analyze the anti-inflammatory effect of ticagrelor combined with rivaroxaban in patients with unstable angina pectoris and type 2 diabetes mellitus.Methods Sixty patients with unstable angina pectoris combined with type 2 diabetes treated in our hospital from January 2019 to December 2019 were selected as the observation group,and 20 healthy volunteers were selected as the control group.The differences of sCD40L,IL-6,hsCRP,CEC of peripheral blood samples and quality of life between the observation group and the control group before and after treatment were compared,and the incidence of adverse reactions in the observation group was analyzed.Results There were significant differences in sCD40L,IL-6,hsCRP,CEC of peripheral blood samples and quality of life between the observation group and the control group before treatment,with statistical significance (P<0.05).There was no significant difference between the observation group and the control group in sCD40L,IL-6,hsCRP,CEC of peripheral blood samples and quality of life after treatment (P>0.05).The incidence of cardiovascular and cerebrovascular diseases and organ bleeding in the observation group was 8.3%.Conclusion Treatment of patients with unstable angina and type 2 diabetes with ticagrelor combined with rivaroxaban can effectively improve the serum levels of sCD40L,IL-6,and hsCRP,reduce the CEC of patients’ peripheral blood samples,and improve the quality of life.
作者
王亚菊
WANG Ya-ju(Pingquan Hospital,Pingquan,Hebei 067500)
出处
《智慧健康》
2021年第4期116-118,共3页
Smart Healthcare
关键词
替格瑞洛
利伐沙班
不稳定型心绞痛
2型糖尿病
Ticagrelor
Rivaroxaban
Unstable angina pectoris
Type 2 diabetes mellitus
