摘要
目的探讨儿童静脉使用阿奇霉素的有效性、安全性及循证学依据。方法简述我院一例儿童肺炎支原体肺炎的治疗及用药,检索儿童肺炎支原体肺炎治疗的文献,为该例患者用药查找依据。结果现有系统评价及指南支持轻症肺炎支原体感染口服阿奇霉素治疗,重症感染患者可选择阿奇霉素序贯治疗的方案。口服阿奇霉素与序贯治疗和连续静脉给药相比,治疗有效性相似,但不良反应发生率更低。结论重症肺炎支原体患者可考虑阿奇霉素先静脉后口服的序贯治疗方案,用药期间注意监测可能出现的不良反应。
Objective To explore the efficacy,safety and evidence of intravenous azithromycin in pediatrics for clinical rational use.Methods The treatment of a child diagnosed with mycoplasma pneumoniae pneumonia in our hospital was discussed,and related literatures were searched to find the evidences for the child’s medication.Results Available systematic reviews and guidelines support the idea that oral azithromycin should be administrated to the patient with mild mycoplasma pneumoniae infection,and sequential administration of azithromycin suits for patients with severe infections.Compared with sequential treatment and continuous intravenous administration,oral administration has similar clinical efficacy,but the incidence of adverse event is pretty lower.Conclusion For the treatment of severe mycoplasma pneumoniae infection in children,azithromycin sequential administration can be a good choice than intravenous therapy,potential adverse event caused by azithromycin should be paid attention.
作者
赵小琳
宿怀予
ZHAO Xiao-lin;SU Huai-yu(People's Hospital of Deyang,Deyang,Sichuan 618000)
出处
《智慧健康》
2021年第1期122-124,127,共4页
Smart Healthcare
关键词
阿奇霉素
口服给药
序贯治疗
不良反应
Azithromycin
Oral administration
Sequential administration
Adverse event
