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肠道菌群及其代谢产物对非酒精性脂肪性肝病发病及治疗影响的研究进展

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摘要 非酒精性脂肪性肝病(NAFLD)已成为最常见的肝病,在治疗方面尚无特效药。肠道菌群紊乱及内环境失调可以导致肠道黏膜通透性改变,进而通过肠-肝轴使移位的肠道菌群及其内毒素对肝脏产生慢性炎症作用。肠道菌群代谢产物及益生菌、益生元、合生元、粪菌移植均能使NAFLD的症状得到改善。本综述通过查阅国内外文献,总结了肠道菌群影响NAFLD的相关机制,归纳靶向肠道菌群及其代谢产物对相关疾病的作用,为临床治疗NAFLD提供理论基础。
出处 《河南医学研究》 CAS 2021年第10期1919-1920,F0003,F0004,共4页 Henan Medical Research
基金 河南省科技攻关计划(192102310049)。
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