摘要
目的分析48例川崎病(KD)合并肺炎支原体(MP)感染患儿的临床特征、实验室检测指标水平的变化。方法回顾性分析2012年1月至2018年12月在广州市越秀区儿童医院住院的108例KD患儿资料,其中KD合并MP感染者48例(感染组),KD未合并MP感染者60例(非感染组),对其性别、年龄、发热体温、发热时间、球结膜充血、口唇干裂、杨梅舌、口腔粘膜充血、躯干皮疹、四肢红斑、四肢水肿、肛周脱皮、颈部淋巴结肿大等临床特征以及白细胞计数(white blood cell,WBC)、中性粒细胞(neutrophils,N)、淋巴细胞(lymphocyte,L)、中性粒细胞与淋巴细胞比(neutrophils/lymphocyte,N/L)、血红蛋白(hemoglobin,Hb)、血小板(platelet,PLT)、C反应蛋白(C-reactive protein,CRP)、血清淀粉样蛋白(serum amyloid protein,SAA)、降钙素原(procalcitonin,PCT)、血沉(erythrocyte sedimentation rate,ESR)、肌酸激酶(creatinekinase,CK)、肌酸激酶同工酶(creatine kinase isoenzyme,CKMB)、乳酸脱氢酶(lactate dehydrogenase,LDH)、α-羟丁酸脱氢酶(α-hydroxybutyrate dehydrogenase,HBDH)、天门冬氨酸氨基转移酶(aspartate aminotransferase,AST)、谷丙转氨酶(alanine transaminase,ALT)、白蛋白(albumin,ALB)、总蛋白(total protein,TP)、免疫球蛋白A(immunoglobulin A,IgA)、免疫球蛋白G(immunoglobulin G,IgG)、免疫球蛋白M(immunoglobulin M,IgM)等实验室指标水平进行比较。结果(1)两组患儿之间年龄和性别比较,差异均无统计学意义(均P>0.05)。(2)两组患儿临床特征(体温、发热时间、球结膜充血、口唇干裂、杨梅舌、口腔黏膜充血、躯干皮疹、四肢红斑、四肢水肿、肛周脱皮、颈部淋巴结肿大)比较,差异均无统计学意义(均P>0.05)。(3)两组患儿血常规中WBC、N、L、N/L、Hb、PLT水平以及CRP、SAA、PCT、ESR、CK、LDH、HBDH、AST、ALT、ALB、TP水平之间比较,差异均无统计学意义(均P>0.05)。感染组患儿CKMB为(42.92±5.71)U/L、IgA为(1.02±0.84)g/L、IgG
Objective To analyze the clinical characteristics and laboratory indicators in children with Kawasaki disease(KD)complicated with mycoplasma pneumoniae(MP)infection.Methods The data of 108 children hospitalized in our hospital from 2012 to 2018,including 48 cases of KD with MP infection(an infection group)and 60 cases of KD without MP pneumonia(a non-infection group),were analyzed.The clinical features,including gender,age,fever temperature,fever time,bulbar conjunctival congestion,dry lip,Myrica rubra tongue,oral mucosa congestion,trunk rash,limb erythema,limb edema,perianal desquamation,neck lymph node enlargement,etc.,and levels of laboratory indicators,such as WBC,N,L,N/L,Hb,CRP,SAA,PCT,ESR,CK,CKMB,LDH,HBDH,AST,ALT,ALB,TP,IgG,IgM,IgA,were compared between the two groups.Results There were no statistical differences in age,gender,body temperature,fever time,bulbar conjunctival congestion,dry lip,Myrica rubra tongue,oral mucosal congestion,trunk rash,erythema of limbs,limb edema,perianal desquamation,and neck lymph node enlargement between the two groups(all P>0.05).There were no statistical differences in the levels of WBC,N,L,N/L,Hb PLT,CRP,SAA,PCT,ESR,CK,LDH,HBDH,AST,ALT,ALB,and TP between the two groups(all P>0.05).The levels of CKMB,IgA,IgG,and IgM were(42.92±5.71)U/L,(1.02±0.84)g/L,(7.87±3.05)g/L,and(1.34±0.63)g/L inthe infectiongroup,andwere(30.84±7.23)U/L,(0.82±0.80)g/L,(6.87±3.79)g/L,and(1.02±0.55)g/L in the non-infection group,with statistical differences(all P<0.05).MP infection was associated with the levels of IgA,IgG and IgM(all P<0.05).The correlation of IgM was the highest(β=0.23,P=0.005).Conclusion KD complicated with MP infection is easy to cause myocardial enzyme elevation and immune dysfunction.It is necessary to monitor the children's cardiac and immune functions in clinical treatment.
作者
郭惠娴
赖来清
张宙
于力
廖嘉仪
Guo Huixian;Lai Laiqing;Zhang Zhou;Yu Li;Liao Jiayi(Department of Pediatrics,Guangzhou First People's Hospital,Guangzhou Medical University,Guangzhou 510180,China;Department of Respiration,Children's Hospital of Yuexiu District,Guangzhou 510115,China)
出处
《国际医药卫生导报》
2021年第7期1003-1008,共6页
International Medicine and Health Guidance News
基金
广州市越秀区科技计划项目(2019-WS-001)。
关键词
川崎病
肺炎支原体
儿童
临床特征
实验室指标
Kawasaki disease
Mycoplasma pneumonia
Children
Clinical features
Laboratory indicators
