摘要
目的分析乙肝肝硬化患者采取抗病毒联合微生态制剂治疗的效果。方法研究对象为方便选取该院接收的68例慢性乙肝肝硬化患者,病例入选时间为2018年5月—2020年5月,采用随机方法分组,对照组34例给予单纯抗病毒治疗,研究组34例给予抗病毒^(+)微生态制剂治疗,对比其临床疗效。结果研究组治疗总有效率(97.1%)高于对照组(73.5%),差异有统计学意义(χ^(2)=7.503,P=0.006);研究组LN、HA、IVC、PCⅢ、CD8^(+)、AST、ALT、TBIL水平低于对照组,差异有统计学意义(t=5.859、5.517、3.749、4.628、5.589、4.000、15.097、2.669,P<0.05);研究组CD4^(+)、CD4^(+)/CD8^(+)高于对照组,差异有统计学意义(t=4.622、6.222,P<0.05)。结论对慢性乙型肝炎并肝硬化患者应用抗病毒^(+)微生态制剂治疗可取得更好的临床疗效,并可在一定程度上改善其肝功能、免疫功能、肝纤维化指标,这一治疗方案适宜在临床中推广应用。
Objective To analyze the effect of antiviral combined with microecological agents in patients with hepatitis B and liver cirrhosis.Methods The subjects of the study were 68 patients with chronic hepatitis B cirrhosis received in the hospital.The cases were conveniently selected from May 2018 to May 2020.They were grouped by random methods.34 patients in the control group were given pure antiviral therapy,and 34 patients in the study group were given antiviral^(+)probiotics treatment,comparing its clinical efficacy.Results The total effective rate(97.1%)of the study group was higher than that of the control group(73.5%),and the difference was statistically significant(χ^(2)=7.503,P=0.006);the study group LN,HA,IVC,PCⅢ,CD8^(+),AST,ALT,TBIL level was lower than the control group,and the difference was statistically significant(t=5.859,5.517,3.749,4.628,5.589,4.000,15.097,2.669,P<0.05);the study group CD4^(+),CD4^(+)/CD8^(+)was higher than the control group,and the difference was statistically significant(t=4.622,6.222,P<0.05).Conclusion The application of antiviral^(+)microecological preparations to patients with chronic hepatitis B and liver cirrhosis can achieve better clinical effects,and can improve their liver function,immune function,and liver fibrosis to a certain extent.This treatment plan is suitable for use in patients with chronic hepatitis B and liver cirrhosis,with promotion and application in clinical practice.
作者
冉晓娟
杨京
罗天永
RAN Xiaojuan;YANG Jing;Luo Tianyong(Department of Infectious Diseases,Affiliated Hospital of Guiyang Medical University,Guiyang,Guizhou Province,550000 China)
出处
《中外医疗》
2021年第9期76-78,共3页
China & Foreign Medical Treatment
