摘要
传统观念认为,G蛋白偶联受体通过自身在细胞表面的激活启动信号转导,从而介导细胞响应外界刺激。近年来研究发现了细胞核G蛋白偶联受体(nGPCR)的存在,有别于细胞质膜G蛋白偶联受体(mGPCR),细胞核G蛋白偶联受体具有独特的来源、功能、信号途径和作用模式。本文总结了目前对于细胞核G蛋白偶联受体的研究成果,以期为靶向G蛋白偶联受体的药物研发提供新的理念和思路。
In classical pharmacology,G protein-coupled receptors are characterized to initiate signal transduction through their activation on the cell surface as a cell response to extracellular stimuli.However,nuclear GPCRs(nGPCRs)have been found with particular features differed from plasma membrane GPCRs(mGPCRs)such as origins,functions,signaling pathways and patterns of action.This article summarized the current research progress on nGPCRs,with a purpose to providing new ideas and strategies for drug development targeting GPCRs.
作者
柯璇
洪浩
KE Xuan;HONG Hao(Department of Pharmacology,School of Pharmacy,China Pharmaceutical University,Nanjing 210009,China)
出处
《药学研究》
CAS
2021年第4期247-250,共4页
Journal of Pharmaceutical Research
基金
国家自然科学基金(No.81773714、81573413)。
关键词
细胞核G蛋白偶联受体
核定位序列
核转位
Nuclear GPCRs
Nuclear localization sequence(NLS)
Nuclear translocation
