摘要
目的:临床药师对我院肿瘤化疗患者紫杉醇制剂使用情况进行统计分析,为紫杉醇制剂合理用药提供参考。方法:检索某院“临床安全合理用药决策支持系统”,收集我院2019年7~12月应用紫杉醇制剂的患者病历信息,依据紫杉醇制剂《中国临床肿瘤学会(CSCO)食管癌诊疗指南》(2019版)、《中国临床肿瘤学会(CSCO)乳腺癌诊疗指南》(2019版)等多项合理性评价标准及药品说明书对紫杉醇制剂临床应用情况进行评价。结果:95份应用紫杉醇制剂进行化疗的病历中,有58份病历存在不合理用药问题,用药合理率为38.95%。不合理用药问题类型主要为紫杉醇制剂用量及药物预处理不适宜。药物预处理不适宜包括预处理药物用法用量不当、预处理给药时机不准确及预处理疗程不适宜。结论:某院紫杉醇制剂临床应用合理率较低,一方面临床应规范注射用紫杉醇(白蛋白结合型)给药用量,确保患者治疗效果;另一方面,医师需重视紫杉醇制剂药物预处理过程,规范预处理药物的给药时机、用药剂量及疗程,保障患者用药安全。
Objective:The use of paclitaxel in tumor chemotherapy patients in our hospital was statistically analyzed by clinical pharmacists to provide reference for rational drug use of paclitaxel.Methods:Through“decision support system for clinical safe and rational drug use”,the clinical data of patients received formulations of paclitaxel from July to December in 2019 was collected,and the rationality of the clinical application of paclitaxel formulations were evaluated according to the drug instructions,Guidelines of Chinese Society of Clinical Oncology(CSCO)for the Diagnosis and Treatment of Esophageal Cancer(2019 edition),and Guidelines of Chinese Society of Clinical Oncology(CSCO)for Breast Cancer Diagnosis and Treatment(2019 edition),etc.Results:A total of 95 patients received chemotherapy with paclitaxel formulations,of which 58 had unreasonable drug use,and the rational rate of drug use was 38.95%.The main types of unreasonable drug use were the impropriety dosage of paclitaxel formulations and improper drug pretreatment.The improper drug pretreatment included inappropriate usage and dosage,inappropriate timing of administration,inappropriate course of treatment.Conclusion:The retionality rate of the use of paclitaxel formulations in our hospital is low.On the one hand,the dosage of paclitaxel(albumin bound)should be standardized to ensure the treatment effect of patients.On the other hand,physicians should pay attention to the drug pretreatment of paclitaxel,and standardize the timing,dosage and course of the use of the pretreatment drugs in order to ensure safe medication for patients.
作者
宇文利霞
时绘绘
孔应利
王丽华
YUWEN Lixia;SHI Huihui;KONG Yingli;WANG Lihua(Department of Pharmacy, the Third Hospital of Xingtai, Hebei Xingtai 054000, China)
出处
《中国医药导刊》
2021年第4期306-309,共4页
Chinese Journal of Medicinal Guide
基金
2019年邢台市市级科技计划自筹经费项目(项目编号:2019ZC267,项目名称:临床药师药学实践对胸外科合理用药影响的研究)。
关键词
紫杉醇
合理用药
预处理
临床药师
Paclitaxel
Rational drug use
Pretreatment
Clinical pharmacists
