摘要
烟酰胺单核苷酸(NMN)是烟酰胺嘌呤二核苷酸的前体物质,对老年退行性疾病有一定的治疗作用。本文从增加NMN的稳定性及利用度考虑,将其制备成NMN肠溶胶囊并对其进行质量标准研究。NMN肠溶胶囊的平均含水量为2.54%;平均装量为300.73 mg;平均崩解时限为30.29 min;利用紫外-可见分光光度法对NMN肠溶胶囊进行含量检测,测得烟酰胺单核苷酸的平均含量为130.43 mg/粒。
Nicotinamide mononucleotide(NMN)is the precursor of nicotinamide adenine dinucleotide,which has a certain therapeutic effect on senile degenerative diseases.From the consideration of increasing the stability and availability of NMN,it was prepared into NMN enteric-coated capsules and the quality standards were studied.The average water content of NMN enteric-coated capsules was 2.54%;the average filling volume was 300.73 mg;the average disintegration time was 30.29 minutes;the content of NMN enteric-coated capsules was detected by Uv-spectrophotometry,and the average content of NMN was 14.25 mg/particle.
作者
冯婷婷
李想
邓乾华
张雪华
夏艳
陈荣彬
廖友林
陶桂英
王晓楠
苟文琼
杨善彬
李荣
Feng Tingting;Li Xiang;Deng Qianhua;Zhang Xuehua;Xia Yan;Chen Rongbin;Liao Youlin;Tao Guiying;Wang Xiaonan;Gou Wenqiong;Yang Shanbin;Li Rong(College of Chemistry,Chongqing Normal University,Chongqing 401331;Engineering Research Center for Biotechnology of Active Substances,Ministry of Education,Chongqing Normal University,Chongqing 401331,China)
出处
《广东化工》
CAS
2021年第5期24-25,共2页
Guangdong Chemical Industry
基金
重庆市高校创新团队项目(CXTDX201601018)
活性物质生物技术教育部工程研究中心开放基金项目(No.20150408,AS201903)
重庆师范大学成果转化项目基金(15XZH08)
重庆师范大学博士启动项目(12XLB006)
重庆市大学生创新创业训练计划项目(S201910637014,S202010637012)
重庆市社会事业与民生保障科技创新专项项目(cstc2015shmszx80060)。
