摘要
目的观察丁苯酞软胶囊联合血塞通治疗急性脑梗死合并2型糖尿病的疗效,并探讨其对患者的颈动脉粥样硬化及炎症因子水平的影响。方法选择2020年5月至2020年11月惠州市第三人民医院神经内科收治的92例急性脑梗死合并2型糖尿病患者进行研究,按随机数表法将患者分为观察组和对照组各46例。对照组患者给予血塞通片口服治疗,观察组患者在对照组治疗的基础上联合丁苯酞软胶囊治疗,两组均连续治疗4周。4周后比较两组患者的临床疗效,以及治疗前后的炎症因子、血脂、颈动脉内膜中膜厚度(IMT)、斑块面积、斑块数量、美国国立卫生研究院卒中量表评分(NIHSS)和日常生活能力评分(ADL),同时比较其不良反应发生情况。结果观察组患者的治疗总有效率为97.83%,明显高于对照组的86.96%,差异有统计学意义(P<0.05);治疗后,观察组患者的血清同型半胱氨酸(Hcy)、高敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)的水平分别为(13.41±0.70)μmol/L、(8.45±1.20)mg/L、(7.25±1.50)pg/L,明显低于对照组的(17.30±0.66)μmol/L、(13.08±1.31)mg/L、(12.40±1.73)pg/L,差异均有统计学意义(P<0.05);治疗后观察组患者的总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白(LDL-C)水平分别为(4.15±0.60)mmol/L、(1.14±0.35)mmol/L、(2.36±0.20)mmol/L、(1.74±0.25)mmol/L,对照组分别为(5.22±0.48)mmol/L、(1.71±0.33)mmol/L、(2.02±0.28)mmol/L、(2.80±0.30)mmol/L,观察组患者的TC、TG、LDL-C明显低于对照组,HDL-C明显高于对照组,差异均具有统计学意义(P<0.05);治疗后,观察组患者的颈动脉IMT、斑块面积、斑块数量分别为(3.23±0.35)mm、(13.53±2.70)mm^(2)、(6.02±1.35)个,明显小(少)于对照组的(2.90±0.44)mm、(11.26±2.68)mm^(2)、(7.67±1.42)个,差异均具有统计学意义(P<0.05);治疗后,观察组患者的NIHSS评分为(4.37±0.56)分,明显低于对照组的(8.12±0.52)分,ADL评分�
Objective To observe the efficacy of butylphthalide soft capsule combined with Xuesaitong in the treatment of acute cerebral infarction combined with type 2 diabetes,and to explore its effect on carotid atherosclerosis and the level of inflammatory factors in patients.Methods A total of 92 patients with acute cerebral infarction complicated with type 2 diabetes mellitus,who admitted to Department of Neurology,Huizhou Third People’s Hospital from May 2020 to November 2020,were selected and divided into the observation group and the control group according to random number table method,with 46 patients in each group.The control group was treated with Xuesaitong tablets orally,and the observation group was treated with butylphthalide soft capsule on the basis of the control group,both for 4 consecutive weeks.After 4 weeks of treatment,the clinical efficacy of the two groups of patients,as well as the inflammatory factors,blood lipids,carotid artery intima-media thickness(IMT),plaque area,number of plaques,National Institutes of Health Stroke Scale Score(NIHSS)and daily routine before and after treatment,Activity of Daily Living(ADL),the occurrence of adverse reactions of the two groups were compared.Results After treatment,the total effective rate of the observation group was 97.83%,which was significantly higher than 86.96%of the control group(P<0.05);the levels of inflammatory factors including serum homocysteine(Hcy),high sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6)in the observation group were(13.41±0.70)μmol/L,(8.45±1.20)mg/L,(7.25±1.50)pg/L,respectively,which were significantly lower than corresponding(17.30±0.66)μmol/L,(13.08±1.31)mg/L,(12.40±1.73)pg/L of the control group(all P<0.05);the levels of total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)in the observation group were(4.15±0.60)mmol/L,(1.14±0.35)mmol/L,(2.36±0.20)mmol/L,(1.74±0.25)mmol/L,respectively,which were significantly lower than corresponding
作者
李乐
黄丽霞
刘娟丽
常保强
LI Le;HUANG Li-xia;LIU Juan-li;CHANG Bao-qiang(Department of Neurology,Huizhou Third People's Hospital,Huizhou 516000,Guangdong,CHINA)
出处
《海南医学》
CAS
2021年第8期966-969,共4页
Hainan Medical Journal
基金
广东省惠州市科技计划项目(编号:2020Y201)。
关键词
急性脑梗死
2型糖尿病
丁苯酞软胶囊
疗效
血塞通
炎症因子
血脂
动脉粥样硬化
Acute cerebral infarction(ACI)
Type 2 diabetes
Butylphthalide soft capsule
Curative effect
Xuesaitong
Inflammatory factors
Blood lipid level
Atherosclerosis
