摘要
全氟化合物(perfluorinated compounds,PFCs)是一类在环境和生物体内广泛存在的持久性有机污染物,已有研究表明其与肝脏毒性、免疫毒性、神经毒性等有关。近年来,越来越多的研究提示PFCs具有内分泌干扰效应,其生殖毒性备受关注,尤其是其对性激素合成分泌的影响。当性激素水平紊乱时,机体可能出现性分化发育异常、生殖障碍等表现。该文从动物毒理学研究及其机制、人群流行病学研究的角度,对PFCs与性激素水平的关系进行阐述,并对今后研究的方向进行讨论和展望。
Perfluorinated compounds(PFCs)are a class of persistent organic pollutants that are widely distributed in the environment and biota.Studies have shown that PFCs have liver-toxicity,immune-toxicity and neuro-toxicity,etc.In recent years,due to an increasing number of studies suggesting that PFCs have endocrine disrupting effects,their reproductive toxicity has attracted much attention,especially their interference with the synthesis and secretion of sex hormone which may induce abnormalities in sexual differentiation and development,reproductive disorders,etc.This article reviews the relationship of PFCs with sex hormone levels and the potential mechanisms from animal toxicology experiments and epidemiological studies,thus providing the theoretical basis for PFCs research in the future.
作者
汪子夏
姚谦
田英
WANG Zi-xia;YAO Qian;TIAN Ying(Department of Environmental Health,Shanghai Jiao Tong University School of Public Health,Shanghai 200025,China;MOE and Shanghai Key Laboratory of Children's Environmental Health,Xinhua Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China)
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2021年第4期540-545,共6页
Journal of Shanghai Jiao tong University:Medical Science
基金
国家自然科学基金(81773387)
上海交通大学“医工交叉”项目(YG2017MS84)。
关键词
全氟化合物
持久性有机污染物
性激素
perfluorinated compound
persistent organic pollutant
sex hormone
