摘要
目的探讨妊娠期糖尿病(GDM)患者血清同型半胱氨酸(Hcy)水平与不良妊娠结局的相关性。方法选择2018年1月~2020年1月就诊于本溪市中心医院的65例GDM患者作为研究对象。随访至患者分娩,根据妊娠结局分为不良妊娠结局组(n=13)和良好妊娠结局组(n=52)。比较两组的实验室指标;采用Pearson相关性分析GDM患者血清糖化血红蛋白(HbA1c)、空腹血糖(FBG)与Hcy的相关性;采用Logistic回归分析血清HbA1c、Hcy、FBG与不良妊娠结局的关系。结果所有患者中出现不良妊娠结局13例。不良妊娠结局组血清HbA1c、FBG、Hcy水平均高于良好妊娠结局组,差异有统计学意义(P<0.05);Pearson相关性分析结果显示,GDM患者血清HbA1c水平、FBG水平、Hcy水平两两呈正相关(r>0,P<0.01);Logistic回归分析结果显示,GDM患者血清HbA1c(β=1.059,OR=2.883,95%CI=1.255~6.626)、Hcy(β=0.896,OR=2.451,95%CI=1.491~4.028)、FBG(β=0.437,OR=1.548,95%CI=1.122~2.136)水平高表达是不良妊娠结局的危险因素(P<0.05)。结论GDM患者的HbA1c水平与FBG水平、Hcy水平密切相关,血清Hcy、FBG、HbA1c水平高表达与GDM患者不良妊娠结局发生率具有一定相关性,临床可通过检测GDM患者血清Hcy、FBG、HbA1c水平的表达来预测不良妊娠结局的发生风险,指导风险评估与治疗干预。
Objective To explore the correlation between serum homocysteine(Hcy)level and adverse pregnancy outcome in patients with gestational diabetes mellitus(GDM).Methods A total of 65 GDM patients who visited Benxi Central Hospital from January 2018 to January 2020 were selected as study subjects.Patients were followed up until delivery,and divided into adverse pregnancy outcome group(n=13)and good pregnancy outcome group(n=52)according to pregnancy outcomes.Compare the laboratory indexes of the two groups.Pearson correlation was used to analyze the correlation between serum glycosylated hemoglobin(HbA1c),fasting blood glucose(FBG)and Hcy in GDM patients.Logistic regression was used to analyze the relationship between serum HbA1c,Hcy,FBG and adverse pregnancy outcomes.Results Adverse pregnancy outcomes occurred in 13 patients.The levels of serum HbA1c,FBG and Hcy in the adverse pregnancy outcome group were higher than those in the good pregnancy outcome group,the differences were statistically significant(P<0.05).Pearson correlation analysis showed that serum HbA1c,FBG and Hcy levels in GDM patients were positively correlated(r>0,P<0.01).Logistic regression analysis showed that high expression of serum HbA1c(β=1.059,OR=2.883,95%CI=1.255-6.626),Hcy(β=0.896,OR=2.451,95%CI=1.491-4.028),FBG(β=0.437,OR=1.548,95%CI=1.122-2.136)in patients with GDM were risk factors for adverse pregnancy outcomes(P<0.05).Conclusion HbA1c level of GDM patients is closely related to FBG level and Hcy level.The high expression of serum Hcy,FBG and HbA1c has a certain correlation with the incidence of adverse pregnancy outcomes in GDM patients.In clinics,the expression of serum Hcy,FBG and HbA1c levels in GDM patients can be used to predict the risk of adverse pregnancy outcomes and guide risk assessment and therapeutic intervention.
作者
金智一
JIN Zhi-yi(Department of Endocrinology,Benxi Central Hospital,Liaoning Province,Benxi117000,China)
出处
《中国当代医药》
CAS
2021年第11期72-75,共4页
China Modern Medicine
