摘要
膝骨关节炎(osteoarthritis of the knee,KOA)与骨质疏松症(osteoporosis,OP)是骨科领域两大常见疾病,且临床上两者常常同时出现。通过回顾文献,我们发现两种疾病在流行病学、病理机制及治疗等方面具有一定的关联性。认识到OP与软骨下骨吸收在KOA的病理进程中发挥着重要作用,在KOA的早期,尤其是合并有OP的KOA患者,进行抗OP治疗可能对延缓KOA的进展有一定的帮助,但目前尚需要更多的多中心大样本随机对照试验加以证明。
Knee osteoarthritis(Osteoarthritis of the knee,KOA) and osteoporosis(OP) are two common diseases in orthopaedic field,and they often occur simultaneously in clinic.Through reviewing the literature,we found that the two diseases have a certain correlation in terms of epidemiology,pathological mechanism and treatment.It is recognized that OP and subchondral bone resorption play an important role in the pathological process of KOA.In the early stage of KOA,especially in KOA patients with combined OP,anti-op therapy may be helpful to delay the progress of KOA,but more multicentre large sample randomized controlled trials are still needed to prove it at present.
作者
张程
吴忠书
李子祺
沈莹珊
庄至坤
袁颖嘉
何伟
魏秋实
ZHANG Cheng;WU Zhongshu;LI Ziqi;SHEN Yingshan;ZHUANG Zhikun;YUAN Yingjia;HE Wei;WEI Qiushi(Traumatology&Orthopedics Institute of Guangzhou University of Chinese Medicine,Guangzhou 510378,China;First Clinical Medical College,Guangzhou University of Chinese Medicine,Guangzhou 510405,China;Department of Joint Diseases,The Third Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510378,China;Department of Orthopedics,Quanzhou Orthopedic Traumatological Hospital,Fujian Traditional Chinese Medicine University,Quanzhou 362000,China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2021年第4期618-624,共7页
Chinese Journal of Osteoporosis
基金
国家自然科学基金面上项目资助(81573996,81873327)
泉州市卫生计生科研资助项目计划(2015-37)。
