摘要
近年来,肠道菌群与骨质疏松症等骨代谢相关疾病的关系逐渐成为研究热点。肠道菌群可以介导多种信号途径,影响成骨细胞和破骨细胞的相对活性,从而改善骨骼健康。这些途径包括OPG/RANKL/RANK、Wnt/β-catenin和IGF-1/IGF-1R。通过补充益生菌或移植肠道菌群来增加骨量,减少骨量丢失,正成为预防骨质疏松症或缓解儿童营养不良所致生长缺陷的可行性方案。这作为一种内源性宿主调节的"自然"疗法,既安全有效,又易于接受。本文综述了肠道菌群、胰岛素样生长因子1(insulin-like growth factor-1,IGF-1)和骨代谢三者间的相互联系,并在动物模型实验中,总结肠道菌群及其代谢产物短链脂肪酸(short-chain fatty acids,SCFAs)诱导IGF-1产生来调控骨代谢,促进生长发育的具体作用机制,为上述治疗方式提供一定的理论依据。
In recent years,the relationship between gut microbiota and bone metabolism-related diseases such as osteoporosis has gradually become a research hotspot.Gut microbiota can mediate a variety of signal pathways and affect the relative activity of osteoblasts and osteoclasts to improve bone health.These pathways include OPG/RANKL/RANK,Wnt/β-catenin and IGF-1-IGF-1 R.By supplementing probiotics or transplanting gut microbiota to increase bone mass and reduce bone loss is becoming a feasible scheme to prevent osteoporosis or alleviate growth defects caused by malnutrition in children.As a"natural"therapy of endogenous host regulation,it is safe,effective and easy to accept.This paper reviews the relationship among gut microbiota,insulin-like growth factor-1(IGF-1) and bone metabolism,and summarizes the specific mechanism of IGF-1 production induced by gut microbiota and its metabolites short-chain fatty acid(SCFAs) to regulate bone metabolism and promote growth and development in animal model experiments,so as to provide a theoretical basis for the above treatments.
作者
袁志发
张通
蔡金池
方鹏忠
王文己
YUAN Zhifa;ZHANG Tong;CAI Jinchi;FANG Pengzhong;WANG Wenji(Department of Orthopedics,the First Hospital of Lanzhou University,Lanzhou 730000,China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2021年第4期599-604,共6页
Chinese Journal of Osteoporosis
关键词
肠道菌群
骨代谢
胰岛素样生长因子1
短链脂肪酸
gut microbiota
bone metabolism
insulin-like growth factor-1
short-chain fatty acids
