摘要
目的探究原发性肝癌(PHC)患者血清甲胎蛋白(AFP)、白细胞介素-17(IL-17)、异常凝血酶原Ⅱ(PIVKA-Ⅱ)的表达水平及其临床意义。方法测定144例PHC患者(肝癌组)和50例肝硬化患者(肝硬化组)的血清AFP、IL-17、PIVKA-Ⅱ水平,分析其与术后复发和生存时间的关系。结果肝癌组的AFP、IL-17、PIVKA-Ⅱ水平明显高于肝硬化组(P<0.01)。血清AFP、IL-17、PIVKA-Ⅱ诊断PHC的AUC分别为0.789、0.872、0.935。血清AFP、IL-17和PIVKA-Ⅱ高表达PHC患者的术后复发率高于其低表达PHC患者,累计生存时间明显短于其低表达PHC患者(P<0.05)。结论 PHC患者血清AFP、IL-17、PIVKA-Ⅱ水平呈高表达,且其表达水平与患者术后复发和生存时间有关。
Objective To explore the expression levels and clinical significance of serum alpha fetoprotein(AFP),interleukin-17(IL-17),abnormal prothrombin-Ⅱ(PIVKA-Ⅱ)in patients with primary hepatic carcinoma(PHC).Methods The levels of serum AFP,IL-17 and PIVKA-Ⅱof 144 PHC patients(hepatic carcinoma group)and 50 liver cirrhosis patients(liver cirrhosis group)were detected,and their relationship with postoperative recurrence and survival time were analyzed.Results The levels of AFP,IL-17 and PIVKA-Ⅱin the hepatic carcinoma group were significantly higher than those in the liver cirrhosis group(P<0.01).The AUC of serum AFP,IL-17 and PIVKA-Ⅱin diagnosing PHC were 0.789,0.872 and 0.935,respectively.The recurrence rates of PHC patients with high expression of serum AFP,IL-17 and PIVKA-Ⅱwere higher than those of PHC patients with low expression of serum AFP,IL-17 and PIVKA-Ⅱ,and the cumulative survival time were significantly shorter than those of PHC patients with low expression of serum AFP,IL-17 and PIVKA-Ⅱ(P<0.05).Conclusion The levels of serum AFP,IL-17 and PIVKA-Ⅱare highly expressed in PHC patients,and the expression levels are related to postoperative recurrence and survival time.
作者
曹洪友
丁凤娇
CAO Hongyou;DING Fengjiao(Ankang People's Hospital,Ankang 725000;Ankang Central Hospital,Ankang 725000,China)
出处
《临床医学研究与实践》
2021年第13期108-110,共3页
Clinical Research and Practice
