摘要
有关血管稳态和重构的分子机制一直是近年来的研究热点,也被视为治疗血管损伤性疾病的突破点。大量研究证实,血管损伤修复及病理性重构过程与血管平滑肌细胞(vascular smooth muscle cells,VSMCs)的表型转化、异常增殖与迁移、细胞衰老关系密切。平滑肌22α(smooth muscle 22α,SM22α)蛋白是一种在收缩型VSMCs中大量表达的细胞骨架相关蛋白,可通过与F-actin相互作用促进应力纤维形成,维持VSMCs收缩性,还可作为信号调节分子参与血管稳态和重构。本文综述了近年SM22α在血管稳态和血管重构中作用的研究进展。
The research on the molecular mechanism of vascular injury has been a hot topic in recent years since the mechanism can be targeted for the treatment of vascular injury diseases.A large number of studies have found that vascular injury,repair and pathological remodeling are closely related to phenotype switching,abnormal proliferation and migration,and apoptosis of vascular smooth muscle cells(VSMCs).Smooth muscle 22α(SM22α)is a shape change and transformation sensitive F-actin-binding protein.SM22αdecorates the contractile filament bundles within cultured VSMCs exhibiting differentiated phenotypes.In addition,SM22αis involved in regulation of cell signaling pathways related to vascular homeostasis and vascular remodeling.Here,we reviewed the recent research progress of SM22αin vascular homeostasis and remodeling.
作者
张宁
窦永青
韩梅
ZHANG Ning;DOU Yong-Qing;HAN Mei(College of Basic Medical Sciences,Hebei Medical University,Shijiazhuang 050017,China)
出处
《生理学报》
CAS
CSCD
北大核心
2021年第1期82-88,共7页
Acta Physiologica Sinica
基金
supported by the National Natural Science Foundation of China(No.91739301,91439114 and 91849102)。
