摘要
哮喘是儿童常见的慢性呼吸道疾病,严重影响患儿的身心健康和生活质量。哮喘患儿的气道与肠道存在不同程度黏膜上皮细胞的损伤,而免疫球蛋白A(IgA)是黏膜免疫分泌的主要抗体,可限制菌群定植维持肠道菌群平衡,保护上皮细胞层完整性,从而预防哮喘并改善其预后。此外,中医有云“肺与大肠相表里”,而且“肺肠合治法”是临床治疗哮喘的常用方法,IgA可能是沟通肺与大肠的桥梁。本文从黏膜免疫中IgA对儿童哮喘影响的角度进行文献归纳总结,以期为儿童哮喘的机制研究提供新思路,为临床治疗提供新靶点,为“肺与大肠相表里”提供科学的理论支撑。
Asthma is a common chronic respiratory disease in children,which seriously affects the physical and mental health and quality of life of children.The airways and intestines of children with asthma have varying degrees of damage to the mucosal epithelial cells,and immunoglobulin A(IgA)is the main antibody secreted by mucosal immunity,which can limit the colonization of the intestinal flora and maintain the balance of the intestinal flora and protect the epithelial cell layer Integrity,thereby preventing asthma and improving its prognosis.In addition,Chinese medicine has cloud“exteiror-interior relationship between lung and large intestine”,and“lung and bowel combined treatment”is a common method of clinical treatment of asthma,IgA may be a bridge between the lung and large intestine.This paper summarized the literature from the perspective of the effect of IgA in mucosal immunity on children’s asthma,in order to provide new ideas for the mechanism research of children’s asthma,provide new targets for clinical treatment,and provide scientific theoretical support for“exteiror-interior relationship between lung and large intestine”.
作者
候淑婷
陆远
赵霞
HOU Shuting;LU Yuan;ZHAO Xia(Affiliated Hospital of Nanjing University of Chinese Medicine,Jiangsu Province,Nanjing210029,China;Jiangsu Key Laboratory of Pediatric Respiratory Disease(Tradition Chinese Medicine),Jiangsu Province,Nanjing210023,China;Department of Traditional Chinese Medicine,Children’s Hospital of Soochow University,Jiangsu Province,Nanjing,215000China)
出处
《中国医药导报》
CAS
2021年第10期31-34,共4页
China Medical Herald
基金
国家自然科学基金面上项目(81774367)
国家自然科学基金青年科学基金项目(81904248)
江苏省中医药领军人才项目(SLJ0224)。
关键词
免疫球蛋白A
哮喘
黏膜免疫
肠道菌群
Iimmunoglobulin A
Asthma
Mucosal immunity
Intestinal flora
