摘要
目的:系统性评价丁苯酞治疗一氧化碳中毒性脑病的疗效。方法:在万方数据-数字化期刊群、中国期刊全文数据库(中国知网)、维普科技期刊数据库、PubMed、EMBase、ClinicalKey数据库中,检索2009年1月至2020年8月的相关研究,探索丁苯酞预防及治疗一氧化碳迟发性脑病的疗效。采用RevMan 5.3软件对各效应指标进行荟萃(meta)分析。结果:共纳入13项研究,1140例患者。Meta分析结果显示:丁苯酞能够明显降低一氧化碳中毒患者的迟发性脑病发生率[95%CI(0.10,0.42),P<0.001],明显改善一氧化碳迟发性脑病患者的简易智力状态评分[95%CI(2.91,6.02),P<0.001]和日常生活能力Barthel指数评分[95%CI(11.05,13.10),P<0.001]。结论:丁苯酞能够预防及治疗一氧化碳迟发性脑病,适合临床应用。
Objective:To systematically evaluate the efficacy of butylphthalide in the treatment of carbon monoxide poisoning encephalopathy.Methods:Related studies published from January 2009 to August 2020 were retrived from Wanfang Data-Digitalization Journals,China National Knowledge Infrastructure(CNKI),VIP China Science and Technology Journal Database,PubMed,EMBase and ClinicalKey databases.The efficacy of butylphthalide in the prevention and treatment of carbon monoxide delayed encephalopathy was investigated.The RevMan 5.3 software was used for meta analysis of various effect indexes.Results:A total of 13 studies involving 1140 patients were included in the study.Meta analysis showed that butylphthalide could significantly reduce the incidence of delayed encephalopathy in the patients with carbon monoxide poisoning[95%CI(0.10,0.42),P<0.001],improve the mini-mental state examination scores(MMSE)[95%CI(2.91,6.02),P<0.001],as well as Barthel indexes[95%CI(11.05,13.10),P<0.001]in the patients with carbon monoxide delayed encephalopathy.Conclusion:Butylphthalide could prevent and treat carbon monoxide delayed encephalopathy,and is suitable for clinical application.
作者
肖怡群
华禕铭
钱金
范益生
卢芸
XIAO Yiqun;HUA Yiming;QIAN Jin;FAN Yisheng;LU Yun(Department of Pharmacy,Changhai Hospital,Naval Medical University,Shanghai 200433,China)
出处
《药学服务与研究》
CAS
2021年第2期110-116,共7页
Pharmaceutical Care and Research
关键词
丁苯酞
一氧化碳迟发性脑病
疗效
荟萃分析
butylphthalide
carbon monoxide delayed encephalopathy
efficacy
meta analysis
