摘要
1例6岁女性患儿因过敏性鼻炎给予欧龙马口服滴剂及糠酸莫米松鼻喷雾剂1个月余,症状未好转。因腺样体肥大加用孟鲁司特钠咀嚼片(孟鲁司特钠)4 mg、每晚睡前口服。服药7 d后,出现梦游,1次/周,表现为梦中突然坐起,1 min后躺下入睡。2个月后因患儿鼻部症状减轻停用所有药物,停药1周后未再梦游。1年余后,因患儿鼻炎复发,家长自行予上述3种药物治疗。服药5 d后患儿出现梦游且症状较前加重。继续用药2周后,患儿梦游继续加重。停用孟鲁司特钠咀嚼片,2 d后患儿梦游减轻,1个月后消失。考虑患儿梦游为孟鲁司特钠咀嚼片不良反应,改用氯雷他定5 mg每晚睡前口服。电话随访3个月,患儿未再梦游。
A 6-year-old girl received sinupret oral drops and mometasone furoate aqueous nasal spray for allergic rhinitis for more than 1 month,but her symptoms were not improved.Additional use of oral montelukast sodium chewable tablets 4 mg every night was given due to adenoid hypertrophy.After 7 days of montelukast sodium administration,the girl developed somnambulism once per week,which manifested as sitting up suddenly in the dream and lying down to sleep after 1 minute.Two months later,all drugs were stopped because the nasal symptoms were relieved and no sleepwalking occurred 1 week after drug withdrawal.More than a year later,the above 3 drugs were given by her parents due to the recurrence of rhinitis and the girl developed somnambulism again with worse symptoms 5 days later.After 2 weeks of continued medication,somnambulism continued to worsen.Montelukast sodium was stopped,symptoms of somnambulism were relieved 2 days later and disappeared 1 month later.Considering that somnambulism in the girl was an adverse reaction to montelukast sodium,it was replaced by oral loratadine 5 mg every night.At 3 months of telephone follow-up,the somnambulism did not occur in the girl.
作者
刘苗苗
孙书臣
王帆
Liu Miaomiao;Sun Shuchen;Wang Fan(Clinical Specialty of Integrated Traditional Chinese and Western Medicine,Graduate School of Beijing University of Chinese Medicine,Beijing 100029,China;Department of Otolaryngology,Guanganmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)
出处
《药物不良反应杂志》
CSCD
2021年第3期148-149,共2页
Adverse Drug Reactions Journal
关键词
梦行症
药物相关副作用和不良反应
孟鲁司特钠
梦游
Somnambulism
Drug-related side effects and adverse reactions
Montelukast sodium
Sleepwalking
