摘要
目的探讨鼻窦炎口服液联合布地奈德吸入气雾剂治疗急性鼻窦炎的临床疗效。方法选取2019年6月—2020年9月濮阳市油田总医院收治的88例急性鼻窦炎患者,按照随机数字表法将88例患者分为对照组和治疗组,每组44例。对照组雾化吸入布地奈德吸入气雾剂,2 mL/次,1次/d。治疗组在对照组基础上口服鼻窦炎口服液,10 mL/次,3次/d。两组患者连续治疗14 d。观察两组的临床疗效,比较两组患者临床症状的改善时间,检测两组患者血清中炎性因子水平。结果治疗后,治疗组总有效率为88.64%,对照组为70.45%,组间比较差异有统计学意义(P<0.05)。治疗后,治疗组的鼻塞、流涕、头痛消失时间短于对照组,组间差异有统计学意义(P<0.05)。治疗后,两组的白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)、嗜酸性粒细胞阳离子蛋白(ECP)水平明显降低(P<0.05);且治疗后治疗组的IL-6、IL-1β、ECP水平比对照组低,差异有统计学意义(P<0.05)。结论鼻窦炎口服液联合布地奈德吸入气雾剂可提高急性鼻窦炎的疗效,减轻临床症状,降低炎症介质水平,且安全性良好。
Objective To investigate the clinical effect of Bidouyan Oral Lliquid combined with Budesonide Inhalation Aerosol in treatment of acute sinusitis.Methods Patients(88 cases)with acute sinusitis in Puyang Oilfield General Hospital from June 2019 to September 2020 were randomly divided into control and treatment groups,and each group had 44 cases.Patients in the control group were atomization inhalation with Budesonide Inhalation Aerosol,2 mL/time,once daily.Patients in the treatment group were po administered with Bidouyan Oral Lliquid on the basis of the control group,10 mL/time,three times daily.Patients in two groups were treated for 14 d.After treatment,the clinical efficacies were evaluated,and the improvement times of the main clinical symptoms of the two groups were compared,and the levels of inflammatory factors in the serum of the two groups were detected.Results After treatment,the total effective rate was 88.64%in the treatment group and 70.45%in the control group,and the difference was statistically significant(P<0.05).After treatment,the disappearance times of nasal congestion,runny nose and headache in the treatment group were shorter than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of IL-6,IL-1β,and ECP in two groups were significantly decreased(P<0.05).After treatment,the levels of IL-6,IL-1βand ECP in the treatment group were lower than those in the control group,the difference was statistically significant(P<0.05).Conclusion Bidouyan Oral Lliquid combined with Budesonide Inhalation Aerosol can improve the curative effect of acute sinusitis,relieve clinical symptoms and reduce the level of inflammatory factors,with good safety.
作者
刘敏
陈媛媛
苏磊
孙麦青
LIU Min;CHEN Yuan-yuan;SU Lei;SUN Mai-qing(Department of Otolaryngology,Puyang Oilfield General Hospital,Puyang 457001,China;Department of Otolaryngology,Henan Province Hospital of Traditional Chinese Medicine,Zhengzhou,450000)
出处
《现代药物与临床》
CAS
2021年第3期494-497,共4页
Drugs & Clinic
基金
河南省中医药科学研究专项课题(20182Y2093)。
关键词
鼻窦炎口服液
布地奈德吸入气雾剂
急性鼻窦炎
临床症状的改善时间
炎症因子
Bidouyan Oral Lliquid
Budesonide Inhalation Aerosol
acute sinusitis
improvement time of clinical symptom
inflammatory factor
