摘要
小白菊内酯是从野甘菊等植物中提取分离出来的倍半萜烯内酯,具有显著的抗肿瘤作用。研究证明小白菊内酯具有阻滞细胞周期,抑制上皮间充质转化,抑制肿瘤细胞迁移和侵袭,诱导肿瘤细胞凋亡、自噬,抑制肿瘤血管生成及逆转多耐药性等多种抗肿瘤作用,为临床多靶点抗肿瘤提供新思路。本文综述了小白菊内酯及其衍生物在抗白血病、胶质瘤及肺癌等方面的应用,为其进一步研发和应用提供依据。
Parthenolide is a sesquiterpene lactone isolated from wild chamomile and other plants,and has significant antitumor effects.Research has shown that parthenolide can block the cell cycle,inhibit the epithelial mesenchymal transition,inhibit tumor cell invasion and metastasis,induce tumor cell apoptosis and autophagy,inhibit tumor angiogenesis and reverse multidrug resistance,providing new ideas for clinical multi-target antitumor therapy.Based on research data of parthenolide and its derivatives for leukemia,glioma and lung cancer,this paper reviewed the research progress home and abroad,and hopes to provide reference for further research and application of parthenolide and its derivatives.
作者
史胜利
徐会敏
马利刚
郑晓珂
安娜
王蕾
SHI Sheng-li;XU Hui-min;MA Li-gang;ZHENG Xiao-ke;AN Na;WANG Lei(School of Pharmaceutical Sciences,Henan University of Traditional Chinese Medicine,Zhengzhou 450046;School of Basic Medicine,Henan University of Traditional Chinese Medicine,Zhengzhou 450046)
出处
《中南药学》
CAS
2021年第4期697-704,共8页
Central South Pharmacy
基金
国家重点研发计划-中医药现代化研究专项(No.2019YFC1708802)
2020年度河南省新工科研究与实践项目(No.2020JGLX048)。
