摘要
目的探讨不同年龄组多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者抗苗勒氏管激素(anti-mullerian hormone,AMH)水平及其接受体外受精/卵细胞浆内单精子注射-胚胎移植(vitro fertilization/intracytoplasmic sperm injection-embryo transfer,IVF/ICSI-ET)治疗后助孕结局情况。方法回顾性分析宁夏医科大学总医院行IVF/ICSI-ET助孕的PCOS患者471例及同期就诊的输卵管因素不孕的非PCOS患者892例(对照组),并分别按年龄分为低龄组(<35岁组)和高龄组(≥35岁组)。比较不同年龄组AMH水平及IVF/ICSI-ET治疗后助孕结局。结果对照组AMH水平低龄组高于高龄组,低龄组获卵数、受精率、MII卵率、优胚率、妊娠率、种植率、活产率、流产率等各项指标均优于高龄组(P均<0.05);PCOS患者高、低龄组AMH水平两组比较差异无统计学意义(P>0.05),临床妊娠率和活产率低龄组高于高龄组(P均<0.05);PCOS低龄组的AMH、移植取消率、获卵数、受精率PCOS低龄组均高于对照低龄组(P均<0.05);MII卵裂率对照组低龄组高于PCOS低龄组(P<0.05);两组妊娠率和活产率、流产率比较差异无统计学意义(P均>0.05)。PCOS高龄组AMH、获卵数均高于对照高龄组(P均<0.05)。两组妊娠率、活产率比较差异均无统计学意义(P均>0.05)。结论不同年龄组PCOS患者AMH水平随年龄变化不大,AMH评估PCOS患者卵巢储备功能无明显意义;与非PCOS患者一样,其最终的妊娠结局如临床妊娠率及活产率随年龄增长而下降。
Objective To analyze the level of AMH and the outcome of assisted pregnancy after IVF/ICSI in PCOS patients of different ages.Methods 471 PCOS patients with IVF/ICSI-ET and 892 patients with tubal infertility were analyzed retrospectively.They were divided into two groups according to their ages:the younger group(<35 years)and the older group(≥35 years).AMH levels and pregnancy outcomes after IVF/ICSI treatment in different age groups were compared.Results In non-PCOS group,the level of AMH,the number of oocytes obtained,the rate of fertilization,the rate of MII oocyte,the rate of excellent embryo,the rate of pregnancy,the rate of live birth,and the rate of abortion and other indicators in the young group were all better than those in the old group(P all<0.05).In PCOS group,the level of AMH had no significant difference between the two age groups(P>0.05).The clinical pregnancy rate and live birth rate in the low age group were significantly higher than those in the old age group(P all<0.05);the level of AMH,the cancellation rate of transplantation,the number of eggs obtained and the fertilization rate of the young PCOS group were higher than that of the young non-PCOS group;the cleavage rate of MII inthe young non-PCOS group was higher than that of the young PCOS group(P all<0.05);there was no statistical difference in pregnancy rate,live rate and abortion rate between the two groups(P all>0.05).In old group,AMH,the number of oocytes in PCOS group was significantly higher than that in the non-PCOS group(P all<0.05).There was no significant difference in pregnancy rate and live birth rate between the two groups(P all>0.05).Conclusion The level of AMH and the number of oocytes in PCOS patients have little change with age,and the significance of AMH in evaluating ovarian reserve function is not obvious for PCOS patients.However,as with non PCOS,the final pregnancy outcome,such as clinical pregnancy rate and live birth rate,decreased with age.
作者
袁莹莹
宋晓霞
赵君利
景万红
哈灵侠
岳荣
YUAN Yingying;SONG Xiaoxia;ZHAO Junli;JING Wanhong;HA Lingxia;YUE Rong(General Hospital of Ningxia Medical University,Yinchuan 750004,China;Key Laboratory of Fertility Preservation and Maintenance,Ministry of Education,Ningxia Medical University,Yinchuan 750004,China)
出处
《宁夏医科大学学报》
2021年第3期239-243,共5页
Journal of Ningxia Medical University
基金
宁夏医科大学校级课题(XM2016076)。
关键词
多囊卵巢综合征
抗苗勒氏管激素
助孕结局
polycystic ovary syndrome
anti-mullerian hormone
pregnancy outcomes
