摘要
临床工作中观察到瘢痕疙瘩存在与增生性瘢痕等其他类型瘢痕显著不同的特性,瘢痕疙瘩的生长通常超出原始伤口边界,向周围皮肤不断入侵,瘢痕疙瘩经手术、糖皮质激素注射等治疗后存在一定的复发率,提示瘢痕疙瘩具有一定的肿瘤特征,因此不能仅仅站在瘢痕的角度看待瘢痕疙瘩。本文试图以肿瘤的视角重新描述瘢痕疙瘩的发病机制,从生长信号的自给自足、避免凋亡、异常血管生成等方面总结瘢痕疙瘩的肿瘤特征。
In clinical work,it is observed that keloid has significantly different characteristics from other types of scar such as hypertrophic scar.The growth of keloid usually exceeds the margin of original wound and continuously invades the surrounding skin,and keloid has a certain recurrence rate after various treatment measures such as surgery and glucocorticoid injection,etc.The above phenomenon suggests that keloid has certain tumor characteristics,and we cannot judge keloid from the perspective of scar alone.This article attempts to re-describe the pathogenesis of keloid from the perspective of tumor and summarizes the tumor characteristics of keloid from self-sufficiency of growth signal,avoidance of apoptosis,and abnormal angiogenesis,etc.
作者
贾赤宇
陈泠西
Jia Chiyu;Chen Lingxi(Department of Burns and Plastic&Wound Repair Surgery,Xiang'an Hospital of Xiamen University,Xiamen 361102,China)
出处
《中华烧伤杂志》
CAS
CSCD
北大核心
2021年第4期301-305,共5页
Chinese Journal of Burns
基金
福建省自然科学基金(2019J01011)
厦门大学附属翔安医院科研启动项目(PM201809170010)。
