摘要
目的探讨采用^(18)F-氟代脱氧葡糖糖(^(18)F-FDG)正电子发射计算机断层扫描(PET/CT)诊断肝内胆管细胞癌(ICC)分期的效能。方法2017年1月~2020年1月我院收治的107例ICC患者和同期107名体检且身体健康的志愿者,接受^(18)F-FDG PET/CT检查,行TNM分期评估,勾画感兴趣区域,计算最大标准摄取值(SUV max)。所有患者接受手术治疗,术后行组织病理学检查。结果Ⅰ期ICC组SUV max值为(4.1±1.1)、Ⅱ期为(7.2±1.5)、Ⅲ期为(9.3±1.8),均显著高于健康组的【(2.0±0.9),P<0.05】;^(18)F-FDG PET/CT检查显示在107例ICC患者中,TNM分期Ⅰ期为35例,Ⅱ期为47例,Ⅲ期为25例,术后组织病理学检查显示Ⅰ期、Ⅱ期和Ⅲ期分别为34例、48例和24例;经一致性分析,^(18)F-FDG PET/CT诊断ICC患者TNMⅠ期的灵敏度为0.968,特异度为0.500,准确率为0.914,阳性预测值为0.938,阴性预测值为0.667,诊断Ⅱ期的灵敏度为0.976,特异度为0.667,准确率为0.956,阳性预测值为0.976,阴性预测值为0.667,诊断Ⅲ期的灵敏度为0.955,特异度为0.667,准确率为0.920,阳性预测值为0.955,阴性预测值为0.667。结论^(18)F-FDG PET/CT检查能够帮助诊断ICC,并协助TNM分期的评估,具有较高的临床应用价值。
Objective The aim of this study was to investigate the diagnostic efficacy of ^(18)F-FDG PET/CT scan in patients with intrahepatic cholangiocarcinoma(ICC).Methods 107 patients with ICC and 107 healthy persons underwent ^(18)F-FDG PET/CT scan between January 2017 and January 2020,and the TNM staging of tumor was evaluated and the standard uptake value maximum(SUVmax)was culculated.All patients received tumor resection.Results The SUVmax in patients with ICC stageⅠwas(4.1±1.1),in patients with stageⅡwas(7.2±1.5),and in patients with stageⅢwas(9.3±1.8),all significantly higher than[(2.0±0.9),P<0.05]in healthy persons;the FDG PET/CT scan showed TNM stageⅠin 35 cases,stageⅡin 47 cases,and stageⅢin 25 cases,and the post-operational histopathological examination demonstrated TNM stageⅠ,stageⅡand stageⅢwere34 cases,48 cases and 24 cases,respectively;the sensitivity(Se)of ^(18)F-FDG PET/CT scan in the diagnosis of patients with ICC TNM stageⅠwas 0.968,the specificity(Sp)was 0.500,the accuracy(Ac)was 0.914,the positive predictive value(PPV)was 0.938,and the negative predictive value(NPV)was 0.667,in the diagnosis of patients with ICC TNM stagingⅡ,the Se was 0.976,the Sp was 0.667,the Ac was 0.956,the PPV was 0.976,and the NPV was 0.667,and in the diagnosis of patients with ICC TNM stagingⅢ,the Se was 0.955,the Sp was 0.667,the Ac was 0.920,the PPV was 0.955,and the NPV was 0.667.Conclusion The application of ^(18)F-FDG PET/CT scan is helpful for the diagnosis and assessment of TNM stage in patients ICC.
作者
王耀政
王瑜琳
林毅
Wang Yaozheng;Wang Yulin;Lin Yi(Department of Radiology,909^(th) Hospital,Joint Logistics Support Force,Zhangzhou 363000,Fujian Province,China)
出处
《实用肝脏病杂志》
CAS
2021年第3期427-430,共4页
Journal of Practical Hepatology
基金
国家医学教育发展中心科研课题(编号:2013-29-08-205)。
