摘要
目的探讨血清降钙素原(PCT)、高敏C反应蛋白(hs-CRP)评估老年脓毒血症病情严重程度的临床应用价值。方法回顾性分析2018年1月—2020年11月广州市增城区人民医院收治的老年脓毒血症患者82例临床资料,根据病情严重程度分为A组(脓毒血症,n=39)、B组(重度脓毒血症,n=23)及C组(脓毒血症休克,n=20)。收集患者入院1 d血清PCT和hs-CRP水平、急性生理与慢性健康状况评分Ⅱ(APACHEⅡ)。比较3组血清PCT和hs-CRP水平及APACHEⅡ评分。分析血清PCT和hs-CRP水平与APACHEⅡ评分及老年脓毒血症病情严重程度的关系。结果A组、B组和C组的血清PCT和hs-CRP水平及APACHEⅡ评分依次升高(P<0.05)。Pearson线性相关分析结果显示,老年脓毒血症患者的血清PCT和hs-CRP水平与APACHEⅡ评分均呈正相关(r=0.896,0.885,P<0.05)。Kendall相关分析结果显示,老年脓毒血症患者的血清PCT和hs-CRP水平与病情严重程度均呈正相关(r=0.758,0.876,P<0.05)。结论老年脓毒血症患者的血清PCT和hs-CRP水平较高且与病情严重程度密切相关,可用于其病情及预后评估。
Objective To explore the clinical value of serum procalcitonin(PCT)and high-sensitivity C-reactive protein(hs-CRP)in evaluating the severity of sepsis in the elderly.Methods The clinical data of 82 elderly patients with sepsis admitted to the People's Hospital of Zengcheng District,Guangzhou City from January 2018 to November 2020 were retrospective analyzed.The patients were divided into group A(sepsemia,n=39),group B(severe sepsis,n=23)and group C(septic shock,n=20)according to the severity of the disease.The serum PCT and hs-CRP levels,acute physiology and chronic health scores(APACHEⅡ)were collected on the first day of admission.The serum PCT and hs-CRP levels and APACHEⅡscore among the three groups were compared.The relationship between serum PCT and hs-CRP levels with APACHEⅡscore and severity of sepsis in the elderly were analyzed.Results Serum PCT and hs-CRP levels and APACHEⅡscores in group A,group B and group C increased sequentially(P<0.05).The results of Pearson linear correlation analysis showed that serum PCT and hs-CRP levels in elderly patients with sepsis were positively correlated with APACHEⅡscore(r=0.896,0.885,P<0.05).The results of Kendall correlation analysis showed that serum PCT and hs-CRP levels in elderly patients with sepsis were positively correlated with the severity of the disease(r=0.758,0.876,P<0.05).Conclusion The serum PCT and hs-CRP levels of elderly patients with sepsis are relatively high and are closely related to disease severity,which may be used as reference indexes for evaluating the severity of disease.
作者
曹世雄
黄河
刘长波
Cao Shixiong;Huang He;Liu Changbo(The Zengcheng District People's Hospital of Guangzhou City Guangzhou,Guangdong 511300)
出处
《基层医学论坛》
2021年第11期1493-1495,共3页
The Medical Forum
基金
广东省科技计划项目(2017ZC0440)。
