摘要
目的观察氢溴酸西酞普兰片治疗脑卒中后焦虑抑郁伴失眠患者的临床效果及安全性分析。方法选取2017年6月-2020年3月淮安市第一人民医院收治的脑卒中后焦虑抑郁并出现失眠患者153例为研究对象,根据投掷硬币法随机均分为观察组(77例)和对照组(76例)。对照组接受常规药物盐酸帕罗西汀片治疗,观察组采用氢溴酸西酞普兰片治疗。比较2组治疗结果,治疗前后生活质量、抑郁、焦虑、睡眠质量评分及不良反应。结果用药6个月,观察组总有效率为93.51%,高于对照组的80.26%(χ^(2)=5.904,P=0.015)。用药6个月后,2组生活质量分值均升高,且观察组上升幅度大于对照组(P均<0.01);2组SAS、SDS、睡眠质量评分均下降,且观察组下降幅度大于对照组(P均<0.01)。观察组不良反应总发生率为9.10%,低于对照组的36.85%(χ^(2)=16.696,P=0.000)。结论脑卒中后焦虑抑郁伴失眠患者采用氢溴酸西酞普兰片治疗效果明显,可有效改善患者负面情绪,缓解其心理压力,提高治疗总有效率、生活质量,且不良反应少,安全可靠性良好,适于临床推广和使用。
Objective To observe the clinical effect and safety of citalopram hydrobromide tablets in treatment of post-stroke anxiety and depression complicated with insomnia.Methods 153 cases of patients with post-stroke anxiety and depression complicated with insomnia and who treated in Huai’an First People’s Hospital from June 2017 to March 2020 were selected as the research subjects,and the patients were divided into observation group(77 cases)and control group(76 cases).The control group was treated with paroxetine hydrochloride tablets,and the observation group was given citalopram hydrobromide tablets.The treatment results,scores of quality of life,depression,anxiety,sleep quality and adverse reactions were compared between the two groups before and after treatment.Results After 6 months of treatment,the total effective rate of the observation group was 93.51%,which was higher than 80.26%of the control group(χ^(2)=5.904,P=0.015).The scores of quality of life of the two groups were increased,and the rising range of the observation group was greater than that of the control group(P<0.01);the scores of SAS,SDS and sleep quality of the two groups were decreased,and the decline range of the observation group was greater than that of the control group(P<0.01).The total incidence of adverse reactions in the observation group was 9.10%,which was lower than 36.85%of the control group(χ^(2)=16.696,P=0.000).Conclusion The effects of citalopram hydrobromide tablets in treatment of post-stroke anxiety and depression complicated with insomnia are significant which can effectively improve negative emotions,relieve psychological pressure and improve the treatment efficiency,thus it is suitable for a large number of clinical treatment promotion and use.
作者
高琪
GAO Qi(Huai'an First People's Hospital,Jiangsu Province t Huai'an 223300,China)
出处
《临床合理用药杂志》
2021年第8期7-9,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
脑卒中
焦虑
抑郁
失眠
盐酸帕罗西汀片
氢溴酸西酞普兰片
临床效果
睡眠质量
生活质量
Stroke
anxiety
depression
insomnia
Paroxetine hydrochloride tablets
Citalopram hydrobromide tablets
Clinical effect
Seep quality
Quality of life
