摘要
目的探索不同掺杂酸对聚苯胺包覆载药TiO_(2)纳米管(TNTs)复合材料的pH敏感性释药行为的影响。方法通过化学氧化聚合法分别制备掺杂CA、L-Glu和LABSA的聚苯胺包覆载药TiO_(2)纳米管复合材料(PANI@TNTs-BIT)。采用XRD、FT-IR、TEM及TGA测试确定产物结构、形貌及体系载药量,用UV-vis法测定BIT药物在特征吸收波长下的吸光度,并得出吸光度与浓度间的函数关系式,以揭示复合材料的药物释放量与环境pH之间的关系。结果锐钛矿型TNTs作为防污剂BIT的纳米容器,药物负载高达23%(质量分数)。用PANI包覆后,TNTs-BIT的载药率降为9.8%,结合TEM图,说明形成了较厚的PANI包覆层。酸掺杂后的PANI@TNTs-BIT复合材料具有明显的pH敏感性,当环境pH由8.5逐渐下降至5.8时,掺杂L-Glu和LABSA的PANI@TNTs-BIT中BIT的释放量呈快速增长趋势,尤其是掺杂LABSA的材料,不但具有优异的pH响应性释药行为,而且明显缓解了BIT前期“爆释”问题,表现出了高效防污性能。结论锐钛矿型TNTs可对所负载的BIT药物起到缓/控释作用,而且利用掺杂L-Glu和LABSA的PANI对TNTs-BIT进行包覆后,可实现载药体系及时对环境pH的变化作出响应,从而起到智能调控药物释放量并达到防污的目的。
In this paper,the effect of acids doping on the pH sensitivity of polyaniline-coating drug-loaded TiO_(2) nanotubes(PANI@TNTs-BIT)was explored.The PANI@TNTs-BIT composites were prepared by chemical oxidation polymerization,with CA,L-Glu,and LABSA as doping acids,respectively.The structures and morphologies were characterized by XRD,TEM and FT-IR.At the same time,the drug loading of the composites was determined by TGA test.The absorbance of BIT drug at 225 nm wavelength was measured by the UV-vis method,and the functional formula between its absorbance and concentration was deduced,which was used to reveal the drug release amount of the composites in different pH environments.The results showed that anatase TNTs can act as nano-containers of BIT,and the drug loading rate reaches up to 23%.After being wrapped with PANI coating,the drug loading rate of BIT decreases to 9.8%,which indirectly reflects a thick PANI coating on TNTs-BIT,and this is further confirmed by TEM images.Furthmore,the acid-doped PANI@TNTs-BIT composites showed an excellent pH sensitivity.As the pH of environment decreases(from 8.5 to 5.8),the release amount of BIT from PANI@TNTs-BIT doped with L-Glu and LABSA shows a rapid growth trend.Especially,the composite doped with LABSA not only shows excellent pH-responsive drug release behavior,but also obviously alleviates the“burst release”problem,showing an excellent antifouling property.It concludes that anatase TNTs can alleviate/control the release of the loaded BIT drugs,and after coating TNTs-BIT with PANI doped with L-Glu and LABSA,the drug loading system can respond to the change of environmental pH in time,so as to intelligently control the drug release and achieve the purpose of antifouling.
作者
齐琦
王洪芬
陈守刚
QI Qi;WANG Hong-fen;CHEN Shou-gang(Ocean University of China,Qingdao 266100,China)
出处
《表面技术》
EI
CAS
CSCD
北大核心
2021年第4期267-274,共8页
Surface Technology
基金
国家自然科学基金(51972290,U1806223)
山东省自然科学基金(ZR2017MD016)。
