摘要
目的探讨纤维支气管镜Olympus BF40联合异烟肼注射液在老年支气管结核病人中的临床效果及对炎症因子、肺功能的影响。方法选择2017~2018年治疗的老年支气管结核病人122例作为研究对象,根据治疗方法分为对照组(n=61)和观察组(n=61)。对照组给予3HRZE/9HRE常规抗结核方案治疗,观察组在对照组基础上加用纤维支气管镜Olympus BF40联合异烟肼注射液治疗,治疗6个月后,比较2组痰菌阴转率、炎症因子及肺功能水平。结果观察组治疗后3个月、6个月痰菌转阴率分别为80.33%、91.80%,均高于对照组的62.30%和73.77%(χ^(2)=5.33、6.89,P=0.04、0.04);观察组治疗后6个月干扰素-γ(IFN-γ)水平高于对照组(t=6.538,P<0.01),CRP、IL-6水平低于对照组(t=8.435、4.981,P均<0.01);观察组治疗后6个月FEV1、FEV1/FVC与每分钟最大通气量(MVV)水平均高于对照组(t=6.348、10.214、5.391,P均<0.01);2组治疗过程中不良反应发生率差异无统计学意义(χ^(2)=1.291,P=0.536)。结论Olympus BF40联合异烟肼注射液有助于提高老年支气管结核病人痰菌阴转率,改善炎症因子及肺功能水平,值得推广应用。
Objective To investigate the clinical effect of fibrobronchoscope Olympus BF40 combined with isoniazid injection in the elderly patients with bronchial tuberculosis and its influence on the inflammatory factors and pulmonary function.Methods A total of 122 elderly patients with bronchial tuberculosis who were treated from January 2017 to December 2018 were selected and divided into control group(n=61)and observation group(n=61)according to the treatment methods.The control group was given 3HRZE/9HRE treatment,and the observation group was treated with fibrobronchoscope Olympus BF40 combined with isoniazid injection on the basis of the control group.After 6 months of treatment,the rate of sputum negative conversion,the levels of inflammatory factors and lung function of the two groups were compared.Results The sputum negative conversion rates of the observation group were 80.33%and 91.80%3 months and 6 months after treatment,compared with 62.30%and 73.77%in the control group respectively.The level of interferon-γin the observation group was higher,and the levels of CRP and IL-6 were lower than those in the control group(P<0.01);The levels of forced expiratory volume in one second(FEV1),FEV1/forced vital capacity(FVC)and maximal voluntary ventilation(MVV)of the observation group were higher than those of the control group 6 months after treatment(P<0.01).There was no significant difference in the incidence rate of adverse events between the two groups(χ^(2)=1.291,P=0.536).Conclusions Olympus BF40 combined with isoniazid injection in the elderly patients with bronchial tuberculosis is helpful to improve the negative conversion rate of sputum bacteria,improve the levels of inflammatory factors and pulmonary function,which is worthy of promotion and application.
作者
巴清云
韩庆
BA Qing-yun;HAN Qing(Department of Pulmunary Disease, Changzhou Third Hospital, Changzhou 213000, China)
出处
《实用老年医学》
CAS
2021年第4期366-369,共4页
Practical Geriatrics
基金
江苏省卫计委科研课题(20160206)。
关键词
异烟肼注射液
支气管结核
痰菌阴转率
炎症因子
肺功能
老年人
isoniazid injection
bronchial tuberculosis
sputum negative rate
inflammatory factor
lung function
aged
