摘要
烧伤疼痛一直是烧伤患者治疗及恢复过程中的一个难题,各种类型烧伤疼痛的性质和强度不同,给烧伤科临床医师对烧伤疼痛的判别和治疗带来了巨大挑战。阿片类药物作为临床治疗烧伤疼痛的首选药,镇痛效果好,但具有不良反应较多、耐药性、成瘾性等问题。氟比洛芬酯是临床上广泛使用的非甾体类抗炎药(NSAID),通过抑制前列腺素(PG)合成,并降低脊髓和中枢的敏感性,减少痛觉冲动,发挥镇痛作用。由于氟比洛芬酯注射液为脂微球载体制剂,具有靶向治疗、起效快、作用时间长的特点,与其他NSAID相比,可以避免胃黏膜局部刺激等不良反应,其超前镇痛及多模式镇痛在烧伤疼痛治疗中的应用,可以明显改善烧伤疼痛的治疗效果,为烧伤各种类型疼痛的治疗提供一种好的治疗方案。
Burn pain has always been a difficult problem in the process of treatment and recovery of burn patients.Different types of burn pain have different nature and intensity.As the first choice in clinical treatment of burn pain,Opioids have good analgesic effect,but there are many adverse reactions,drug resistance,addiction and other problems.Flurbiprofen axetil is a widely used non-steroidal anti-inflammatory drug(NSAID)in clinic.It can inhibit the synthesis of prostaglandin(PG),decrease the sensitivity of spinal cord and central nervous system,reduce the pain impulse and exert the analgesic effect.Compared with other NSAID,flurbiprofen axetil injection can avoid local irritation of gastric mucosa and other adverse reactions,because it is a lipid microsphere carrier and has the characteristics of targeted treatment,fast onset and long duration of action,the application of preemptive analgesia and multi-mode analgesia in the treatment of burn pain can obviously improve the treatment effect of burn pain and provide a good treatment plan for all kinds of burn pain.
作者
张铭
陈铭锐
Zhang Ming;Chen Mingrui(Clinical Medical College of Weifang Medical College, Weifang 261053, China;Department of Burns and Plastic Surgery, 960th Hospital, Joint Logistics Support Force, Jinan 250031, China)
出处
《中华损伤与修复杂志（电子版）》
CAS
2021年第2期143-146,共4页
Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)
关键词
烧伤
镇痛
消炎药
非甾类
氟比洛芬酯
研究进展
Burns
Analgesia
Anti-inflammatory agents,non-steroidal
Flurbiprofen axetil
Research progress
