摘要
目的分析重症新型冠状病毒肺炎(COVID-19)患者的临床特点,以找出重症预测指标。方法回顾性收集广州医科大学附属第八人民医院2020年1月22日至2月15日收治的272例COVID-19患者的一般情况及住院首次实验室及影像学检查资料,依据临床分型分为非重症组(n=236)和重症组(n=36)进行对照分析。结果重症组患者的平均年龄为(60.53±11.20)岁,明显大于非重症组的(46.84±15.73)岁,差异有统计学意义(P<0.05);两组患者的性别、发热、乏力、寒战、食欲不振纳差、头晕症状,合并高血压史比较差异均具有统计学意义(P<0.05);重症组和非重症组患者的血淋巴细胞(0.90×10^(9)/L vs 1.42×10^(9)/L),血小板(170.00×10^(9)/L vs 187.00×10^(9)/L),动脉血氧分压(73.50 mmHg vs 96.00 mmHg)的绝对值中位数比较,重症组明显低于非重症组,差异均有统计学意义(P<0.05);重症组和非重症组患者的肌酸激酶(123.00 U/L vs 68.00 U/L)、谷草转氨酶(32.10 U/L vs 20.10 U/L)、乳酸脱氢酶(305.50 U/L vs 179.00 U/L),C反应蛋白(37.02 mg/L vs 26.55 mg/L)、降钙素原(0.09 ng/mL vs 0.04 ng/mL)、D-二聚体(1700.00μg/L vs1090.00μg/L)绝对值中位数,FbG、APTT升高率、尿蛋白阳性率比较,重症组明显高于非重症组,差异均具有统计学意义(P<0.05)。结论COVID-19患者的部分临床特征、实验室检查可为患者是否出现重症提供有价值的预测。
Objective To analyze the clinical characteristics of severe corona virus disease 2019(COVID-19)patients and to search for predictive parameters for severe cases.Methods The general characteristics,the first laboratory examination and imaging data of 272 eligible COVID-19 patients,who admitted to Guangzhou Eighth People's Hospital,Guangzhou Medical University from January 22,2020 to February 15,2020,were retrospectively analyzed.The patients were divided into the non-severe group(n=236)and severe group(n=36),and non-severe participants were used as controls.Results The mean age of patients in the severe group was(60.53±11.20)years versus(46.84±15.73)years in the non-severe group(P<0.05).There were significant differences in gender,fever,fatigue,chagrin,anorexia,dizziness,history of hypertension between the two groups(all P<0.05).The median absolute value of blood lymphocytes,platelets,arterial oxygen partial pressure in the severe group were 0.90×10^(9)/L,170.00×10^(9)/L,73.50 mmHg,respectively,which were significantly lower than corresponding 1.42×10^(9)/L,187.00×10^(9)/L,96.00 mmHg in the non-severe group(all P<0.05).The levels of creatine kinase,glutamic oxalate transaminase,lactate dehydrogenase,CRP,procalcitonin,and D-dimer in the severe group were 123.00 U/L,32.10 U/L,305.50 U/L,37.02 mg/L,0.09 ng/mL,and 1700.00μg/L,respectively,which were significantly higher than corresponding 68.00 U/L,20.10 U/L,179.00 U/L,26.55 mg/L,0.04 ng/mL,and 1090.00μg/L in the non-severe group,while the elevated rate of FbG and APTT,positive rate of urine protein were also significantly higher in the severe group than those in the non-critical group(all P<0.05).Conclusion Some of the clinical features and laboratory tests of COVID-19 patients can provide valuable early warning of severe cases.
作者
王禹冰
罗洁
蒋慧荣
陈思睿
潘志麟
韩亚娟
WANG Yu-bing;LUO Jie;JIANG Hui-rong;CHEN Si-rui;PAN Zhi-lin;HAN Ya-juan(Department of Thoracic Surgery,Guangzhou Eighth People's Hospital Affiliated to Guangzhou Medical University,Guangzhou 510060,Guangdong,CHINA;Department of Endocrinology and Metabolism,Guangzhou Eighth People's Hospital Affiliated to Guangzhou Medical University,Guangzhou 510060,Guangdong,CHINA)
出处
《海南医学》
CAS
2021年第7期885-888,共4页
Hainan Medical Journal
关键词
新型冠状病毒感染肺炎
重症
临床特点
实验室检查
临床分型
预警指标
Corona virus disease 2019(COVID-19)
Severe case
Clinical characteristics
Laboratory examination
Clinical classification
Early warning parameters
