摘要
肿瘤在生长与恶化的过程中,伴随着具有乏氧、低pH值、氧化应激增加、高浓度谷胱甘肽(glutathione,GSH)及过表达的酶等一系列异常特征的微环境。这些因素虽然影响或限制了肿瘤的治疗,但同时为针对癌症的诊断与新型治疗策略提供了可能的途径。近年来,根据肿瘤微环境(tumor microenvironment,TME)特性,不同响应型的纳米制剂不断地被开发并初步应用于癌症诊疗中。本文首先简要介绍TME的典型特征;其次,详细总结相应乏氧响应型、pH响应型、氧化还原响应型、酶响应型、双重及多重响应型纳米制剂的设计原理和研究进展;最后,对TME响应型纳米制剂存在的挑战与未来发展趋势进行一定的展望。
During growth and progression,the microenvironment of tumors suffers a series of abnormal characteristics,which include hypoxia,acid pH,increased oxidative stress,excess glutathione(GSH),as well as certain overexpressed enzymes.Although affect or limit the cancer therapeutic outcomes,these factors provide possible approaches to strategies for cancer detection and novel therapy at the same time.Recently,based on these properties of the tumor microenvironment(TME),various kinds of responsive nano-platforms have been continuously developed and applied in cancer theranostics preliminarily.Thus,this review would introduce the typical features of TME firstly,then detailly summarize the design principles and research progress of corresponding hypoxiaresponsive,pH-responsive,redox-responsive,enzyme-responsive,dual-responsive and multi-responsive nanoplatforms.Finally,the challenges and the perspectives of the TME-responsive nano-platforms are briefly discussed.
作者
杨雨琦
巩飞
柏上
程亮
YANG Yu-qi;GONG Fei;BAI Shang;CHENG Liang(Institute of Functional Nano and Soft Materials and Collaborative Innovation Center of Suzhou Nano Science and Technology,Soochow University,Suzhou 215123,China)
出处
《药学学报》
CAS
CSCD
北大核心
2021年第2期465-475,共11页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(51302180)
国家973计划项目(2016YFA0201200).
关键词
肿瘤微环境
刺激响应
纳米医学
递药系统
诊断
tumor microenvironment
stimuli-responsive
nanomedicine
drug delivery system
diagnosis
