摘要
目的探讨糖尿病前期对缺血性卒中患者发生卒中后抑郁(PSD)的影响。方法选取本院2016年1月~2019年6月间收治200例急性缺血性卒中患者,依据患者血糖水平分为正常血糖组(n=80)与糖尿病前期组(n=120),糖尿病前期组依据自愿接受干预控制原则分为血糖控制亚组(n=68)、无血糖控制亚组(n=52)。分别于患者入院时、卒中后2w、卒中后3个月以及卒中后6个月诊断并评估患者抑郁程度,对比分析正常血糖组与糖尿病前期组(血糖控制亚组、无血糖控制亚组)患者PSD患病率以及卒中后6个月各组患者抑郁程度情况。结果正常血糖组与糖尿病前期组患者入院时、卒中后2w的PSD发生率对比无明显差异(P>0.05);卒中后3个月以及卒中后6个月糖尿病前期组患者PSD发生率相比正常血糖组明显更高(P<0.05);卒中后3个月以及卒中后6个月血糖控制亚组患者PSD发生率低于无血糖控制亚组(P<0.05);卒中后6个月糖尿病前期组患者PSD病情程度相比正常血糖组更严重(P<0.05);卒中后6个月无血糖控制亚组患者PSD病情重于血糖控制亚组(P<0.05);卒中后6个月血糖控制亚组患者PSD病情程度与正常血糖组无明显差异(P>0.05)。结论缺血性卒中合并糖尿病前期患者更易出现卒中后抑郁症,监测缺血性卒中血糖水平并进行血糖控制对于降低卒中后抑郁发生具有作用。
Objective To explore the influence of pre diabetes on post-stroke depression in ischemic stroke patients.Methods From January 2016 to June 2019,200 patients with acute ischemic stroke were divided into normal blood glucose group(n=80)and pre diabetes group(n=120)according to their blood glucose level.Pre diabetes group was divided into blood glucose control group(n=68)and non blood glucose control group(n=52)according to the principle of voluntary intervention and control.At the time of admission,2 weeks,3 months and 6 months after stroke,the depression degree of the patients was diagnosed and evaluated.The prevalence of PSD and the depression degree of the patients in the normal blood glucose group and the pre diabetes group(blood glucose control group,non blood glucose control group)were compared and analyzed.Results There was no significant difference in the incidence of PSD between the normal blood glucose group and the pre diabetes group at the time of admission and 2 weeks after stroke(P>0.05).The incidence of PSD in the pre diabetes group at 3 and 6 months after stroke was significantly higher than that in the normal blood glucose group(P<0.05).The incidence of PSD in the blood glucose control group at 3 and 6 months after stroke was significantly lower than that in the non blood glucose control group The level of PSD in the pre diabetes group was significantly higher than that in the normal blood glucose group(P<0.05).The level of PSD in the non blood glucose control group was significantly higher than that in the blood glucose control group(P<0.05).The level of PSD in the blood glucose control group was no significant difference compared with the normal blood glucose group(P>0.05).Conclusion The ischemic stroke patients with prediabetes were more likely to suffer from poststroke depression.It was important to monitor the blood glucose level of ischemic stroke and control the blood glucose level in order to reduce the incidence of post-stroke depression.
作者
院晓英
穆朋欣
胡宛平
黄春水
YUAN Xiaoying;MU Pengxin;HU Wanping(The First People's Hospital of Wolong District,Nanyang City,Henan Province,Nanyang 473000,China)
出处
《国际精神病学杂志》
2021年第1期88-91,共4页
Journal Of International Psychiatry
