摘要
目前,婴幼儿、新生儿甚至是胎儿在全身麻醉下行手术或检查已不鲜见。部分全身麻醉药物可通过诱导神经细胞凋亡、突触传递障碍等方式导致远期认知和学习记忆功能缺陷的相关研究已有报道。因此,研究全身麻醉药诱导的发育期神经毒性及其相关干预药物的开发对于保证婴幼儿的健康发育十分重要。文章更新汇总了目前有关调节全身麻醉药物诱导的发育期神经毒性的药物研究进展,这些药物可通过减轻细胞凋亡、突触损伤、海马神经元破坏、降低炎症因子表达、激活保护神经细胞通路等方式缓解全身麻醉药物诱导的神经毒性。
Currently,general anesthesia is widely used in surgeries or examinations for infants,newborns and even fetuses.Reports have demonstrated that some general anesthesia agents may cause long-term deficits in cognitive learning and memory through inducing neuronal apoptosis and synaptic dysfunction.Therefore,it is of importance to investigate the developmental neurotoxicity induced by general anesthesia drugs and related agents to ensure the health of infants and children.This article summarizes the research progress on the agents that regulate the developmental neurotoxicity induced by general anesthesia drugs.The agents can alleviate the neurotoxicity induced by general anesthesia drugs through reducing cell apoptosis,synaptic damage and hippocampal neuron destruction,decreasing the expression of inflammatory factors,and activating the protective nerve cell pathway.
作者
周维
林雪梅
Zhou Wei;Lin Xuemei(Department of Anesthesiology,West China Second University Hospital,Key Laboratory of Birth Defects and Related Diseases of Women and Children,Sichuan University,Ministry of Education,Chengdu 610041,China)
出处
《国际麻醉学与复苏杂志》
CAS
2021年第2期180-185,共6页
International Journal of Anesthesiology and Resuscitation
关键词
麻醉药
全身
药物毒性
发育期神经系统
Anesthetics,general
Drug toxicity
Developmental nervous system
