摘要
目的:探讨老年支气管哮喘急性发作期糖皮质激素吸入联合孟鲁斯特治疗的NLR、PLR、CRP水平及疗效。方法:选取2017年5月-2020年5月收治的老年支气管哮喘急性发作期患者122例为研究对象,根据其治疗方案,分为研究组(n=52)和对照组(n=70)。对照组在去除诱因、氧疗等常规治疗的基础上采用布地奈德福莫特罗吸入粉雾剂雾化吸入治疗,1-2吸/次,2次/d,连续治疗3个月。研究组在对照组治疗的基础上,口服孟鲁斯特,10 mg/次,1次/d,睡前口服,连续治疗3个月。评价比较两组疗效。检测比较两组治疗前和治疗后(治疗3个月)的中性粒细胞与淋巴细胞比值(Neutrophil to lymphocyte ratio,NLR)、血小板与淋巴细胞比值(Platelet to lymphocyte ratio,PLR)、C反应蛋白(C-reactive protein,CRP)水平。统计比较两组不良反应发生率。结果:研究组治疗有效率为96.15%(50/52),高于对照组的84.29%(59/70),差异有统计学意义(P<0.05)。与同组治疗前比较,两组治疗后的NLR、PLR、CRP水平均降低(P<0.05)。研究组治疗后NLR、PLR、CRP水平均低于对照组(P<0.05)。两组声嘶、眼部疼痛不适、溃疡、口腔念珠菌感染等不良反应发生率比较差异无统计学意义(P>0.05)。结论:老年支气管哮喘急性发作期糖皮质激素吸入联合孟鲁斯特治疗可有效控制炎症反应并提高治疗效果,且安全可靠。
Objective:To investigate the levels of NLR,PLR,CRP and efficacy of glucocorticoid inhalation combined with montelukast treatment during the acute attack of elderly bronchial asthma.Methods:A total of 122 elderly patients with acute bronchial asthma who were admitted from March 2019 to May 2020 were selected as the research objects.According to their treatment method,they were divided into study group(n=52)and control group(n=70).The control group was treated with budesonide formoterol powder aerosol inhalation on the basis of conventional treatments such as removal of inducements and oxygen therapy,1-2 inhalations/time,2 times/d,continuous treatment for 3 months.On the basis of the treatment of the control group,the study group received oral montelukast,10 mg/time,once/d,orally taken before going to bed for 3 months.The treatment efficacy of the two groups was evaluated and compared.The before and after treatment(3 months of treatment)Neutrophil to lymphocyte ratio(NLR),Platelet to lymphocyte ratio(PLR),C-reactive protein(CRP)levels between the two groups were tested and compared.The adverse reactions rate between the two groups was statistically compared.Results:The effective rate of treatment in the study group was96.15%(50/52),which was higher than the 84.29%(59/70)in the control group,And the difference was statistically significant(P<0.05).Compared with those of the same group before treatment,the after treatment NLR,PLR,CRP levels of the two groups decreased(P<0.05).After treatment,the after treatment NLR,PLR,CRP levels of the study group were lower than those of the control group(P<0.05).There was no significant difference in the hoarseness,eye pain and discomfort,ulcers,oral Candida infection and other adverse reactions rate between the two groups(P>0.05).Conclusion:Glucocorticoid inhalation combined with montelukast therapy in the acute exacerbation of elderly bronchial asthma can effectively control the inflammatory response and improve the therapeutic effect,which is safe and reliable.
作者
刘晓玢
黄毅文
LIU Xiao—bin;HUANG Yi-wen(Department of Emergency,Nansha Hospital of Guangzhou first peopled Hospital,Guangdong,511457)
出处
《岭南急诊医学杂志》
2021年第1期36-39,共4页
Lingnan Journal of Emergency Medicine
